Author

M. Tyers

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 3 Cell Biology· 3 Biochemistry· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Research Focus:drug response / drug discovery· 4 Assay:bulk RNA-seq· 3 Research Focus:cell type annotation· 3 Organism:human· 3 Organism:yeast· 3 Research Focus:cell signaling & trafficking· 2 Assay:proteomics· 2

Frequent Co-Authors

J. Coulombe-Huntington· 4 shared S. Tollis· 4 shared C. A. Royer· 3 shared G. Ghazal· 2 shared J. Cheng· 2 shared M. Auer· 2 shared P. Thibault· 2 shared T. Bertomeu· 2 shared

Activity by Year

2018-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 26 mutual co-author links

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4 shared papersCell Biology

J. Coulombe-Huntington

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Author profile →

7 papers

Recent·Most cited

Swi4-dependent SWI4 transcription couples cell size to cell cycle commitment

P. Goswami, A. Ghimire, C. Coffin, J. Cheng, J. Coulombe-Huntington, G. Ghazal, Y. Thattikota, M. Tyers, S. Tollis, C. A. Royer

This study shows that Swi4-dependent transcription couples cell size to cell cycle commitment in budding yeast by regulating Swi4 accumulation and Start timing.

bioRxiv · Nov 29, 2023Cell Biology

Active growth signalling promotes cancer cell sensitivity to the CDK7 inhibitor ICEC0942

G. Wilson, G. Sava, K. Vuina, C. Huard, L. Meneguello, J. Coulombe-Huntington, T. Bertomeu, R. Maizels, J. Lauring, M. Tyers, S. Ali, C. Bertoli, R. A. M. de Bruin

This study identifies active mTOR signaling and cell growth as predictors of cancer cell sensitivity to the CDK7 inhibitor ICEC0942.

bioRxiv · Sep 10, 2021 · PreprintCancer Biology

A nitrogen source-regulated microprotein confers an alternative mechanism of G1/S transcriptional activation in budding yeast

S. Tollis, J. Singh, Y. Thattikota, R. Palou, G. Ghazal, J. Coulombe-Huntington, X. Tang, S. Moore, D. Blake, E. Bonneil, C. A. Royer, P. Thibault, M. Tyers

The paper identifies NRS1, a nitrogen-responsive microprotein in budding yeast, that provides an alternative mechanism for G1/S transcriptional activation under poor nitrogen conditions.

bioRxiv · Apr 20, 2020 · PreprintCell Biology

Chemical-Genetic Interrogation of Nuclear Size Control Reveals Cancer-Specific Effects on Cell Migration and Invasion

A. Rizzotto, S. Tollis, N. T. Pham, J. Wildenhain, N. Zuleger, J. T. Keys, D. Batrakou, J. Culley, S. Zheng, J. Lammerding, N. O. Carragher, V. Brunton, M. Auer, M. Tyers, E. C. Schirmer

The paper identifies compounds that reverse nuclear size changes in cancer cell lines and finds they inhibit cell migration and invasion.

bioRxiv · Jan 10, 2020 · PreprintCancer Biology

G1/S transcription factors assemble in discrete clusters that increase in number as cells grow

L. Black, S. Tollis, G. Fu, J.-B. Fiche, S. Dorsey, J. Cheng, S. Notley, B. Crevier, J. Bigness, M. Nollmann, M. Tyers, C. A. Royer

The paper uses PALM to show SBF/MBF transcription factors form clusters in yeast cells, with cluster number increasing as cells grow.

bioRxiv · Nov 28, 2019Cell Biology

Genetic Landscape of Electron Transport Chain Complex I Dependency in Acute Myeloid Leukemia

I. Baccelli, Y. Gareau, B. Lehnertz, S. Gingras, J.-F. Spinella, A. Beautrait, S. Corneau, N. Mayotte, I. Boivin, S. Girard, T. MacRae, M. Frechette, K. Leveille, J. Krosl, C. Thiollier, , G. Sauvageau

The paper identifies Mubritinib as an ETC1 inhibitor effective against chemotherapy-resistant AML subtypes with OXPHOS hyperactivity and specific mutations.

bioRxiv · Jan 15, 2019 · PreprintCancer Biology

Real-time tracking of complex ubiquitination cascades using a fluorescent confocal on-bead assay

J. Koszela, N. Pham, D. Evans, S. Mann, I. Perez-Pi, S. Shave, D. Ceccarelli, F. Sicheri, M. Tyers, M. Auer

This paper introduces a fluorescent confocal on-bead assay to real-time track ubiquitination cascades and identifies new inhibitor activities against Ube1.

bioRxiv · Feb 21, 2018Biochemistry