N. Scott

Identification and Characterization of the Lipoprotein N-acyltransferase in Bacteroides

This paper identifies and characterizes Lnb, a lipoprotein N-acyltransferase in Bacteroides, showing its role in lipoprotein biosynthesis and its impact on bacterial growth and polysaccharide degradation.

Novel cell-to-cell interactions revealed by cryotomography of a DPANN coculture system

This study uses cryo-ET to reveal intercellular nanotubes between a DPANN archaeon and its host, providing insights into host-DPANN communication and proteomic changes during symbiosis.

Diclofenac sensitizes multi-drug resistant Acinetobacter baumannii to colistin

This paper shows diclofenac sensitizes colistin-resistant A. baumannii to colistin in vitro and in a mouse model, with reduced drug concentrations needed in vivo.

A heptavalent O-antigen bioconjugate vaccine exhibits differential functional antibody responses against diverse Klebsiella pneumoniae isolates

This study develops a heptavalent O-antigen vaccine against Klebsiella pneumoniae, showing varying efficacy against different isolates.

Dual Membrane-Sspanning Anti-Sigma Factors Regulate Vesiculation in Gut Bacteroidota

This study identifies a novel family of Dual Membrane-spanning Anti-sigma factors (Dma) that regulate Outer Membrane Vesicle (OMV) biogenesis in Bacteroides thetaiotaomicron.

Modern Acinetobacter baumannii clinical isolates replicate inside spacious vacuoles and egress from macrophages

This study shows modern A. baumannii clinical isolates replicate inside macrophage vacuoles and escape via lysis, unlike older lab strains.

Direct RNA sequencing and early evolution of SARS-CoV-2

The paper presents the first native RNA sequence of SARS-CoV-2, detailing its transcriptome and epitranscriptome, and infers genetic features and evolutionary rate.

A sulfoglycolytic Entner-Doudoroff pathway in Rhizobium leguminosarum bv. trifolii SRDI565

This paper identifies a sulfoglycolytic Entner-Doudoroff pathway in Rhizobium leguminosarum that allows growth on sulfoquinovose, producing sulfolactate and contributing to bacterial persistence in soil.

Replacing murine insulin 1 with human insulin protects NOD mice from diabetes

This study replaces murine insulin 1 with human insulin in NOD mice, reducing diabetes incidence and showing protective effects against autoimmune responses.

Profiling the E. coli Membrane Interactome Captured in Peptidisc Libraries

This paper uses peptidisc libraries and PCP to profile E. coli membrane interactomes, identifying novel interactions not detectable with detergent-based methods.

POFUT2-mediated O-glycosylation of MIC2 is dispensable for Toxoplasma gondii tachyzoites

This study shows that O-glycosylation of MIC2 by TgPOFUT2 is not essential for Toxoplasma gondii tachyzoite infectivity and plaque formation.

Salmonella effectors SseK1 and SseK3 target death domain proteins in the TNF and TRAIL signaling pathways

This study identifies that Salmonella effectors SseK1 and SseK3 glycosylate death domain proteins in TNF and TRAIL signaling pathways, modulating their function during infection.