G. Dimopoulos

Late sporogonic stages of Plasmodium parasites are susceptible to the melanization response in Anopheles gambiae mosquitoes

This study shows that late-stage Plasmodium parasites in mosquitoes are susceptible to melanization, with distinct immune regulation for different stages.

CRISPR Mediated Transactivation in the Human Disease Vector Aedes aegypti

This paper develops a CRISPRa system in Aedes aegypti to transactivate endogenous genes, demonstrating its ability to overexpress developmental genes and suppress dengue virus.

Bacterial communities of Aedes aegypti mosquitoes differ between crop and midgut tissues

This study compares bacterial communities in midguts and crops of Aedes aegypti mosquitoes, finding differences in composition and function between the two tissues.

AgMESH, a peritrophic matrix-associated protein embedded in Anopheles gambiaemelanotic capsules modulates malaria parasite infection

The paper identifies AgMESH, a mosquito protein associated with melanin-based immunity, and shows its role in peritrophic matrix integrity and malaria parasite infection.

Glyphosate Inhibits Melanization and Increases Susceptibility to Infection in Insects

This study shows glyphosate inhibits melanin production in insects, reducing their survival after infection and increasing susceptibility to pathogens.

Field-deployable molecular diagnostic platform for arbovirus and Wolbachia detection in Aedes aegypti

The paper develops a portable qPCR platform for detecting Zika, dengue virus, and Wolbachia in Aedes aegypti mosquitoes, demonstrating its reliability and sensitivity for field use.

Malaria parasite immune evasion and adaptation to its mosquito host is influenced by the acquisition of multiple blood meals

This study shows that additional blood meals affect Plasmodium parasite development differently in Anopheles mosquitoes, influencing oocyst numbers and immune evasion.

Use of IFNγ/IL10 ratio for stratification of hydrocortisone therapy in patients with septic shock

This paper identifies the IFNγ/IL10 ratio as a biomarker to guide hydrocortisone therapy in septic shock, showing improved survival when treatment aligns with the ratio's prediction.

Regulation of midgut cell proliferation impacts Aedes aegypti susceptibility to dengue virus

This study investigates how midgut cell proliferation in Aedes aegypti affects susceptibility to dengue virus, showing that regenerative responses and Delta/Notch signaling influence vector competence.