Author

A. Buchman

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioengineering· 4 Evolutionary Biology· 1

Signature Assays, Organisms & Methods

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Organism:Drosophila· 3 Approach:genetic perturbation / CRISPR· 3 Organism:Arabidopsis· 2 Approach:experimental assay· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1

Frequent Co-Authors

O. Akbari· 3 shared T. Yang· 3 shared I. Antoshechkin· 2 shared M. Li· 2 shared M. W. Perry· 2 shared O. S. Akbari· 2 shared A. A. James· 1 shared C.-H. Chen· 1 shared

Activity by Year

2016-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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3 shared papersBioengineering

O. Akbari

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

CRISPR Mediated Transactivation in the Human Disease Vector Aedes aegypti

M. Bui, E. D. Benetta, Y. Dong, Y. Zhao, T. Yang, M. Li, I. A. Antoshechkin, A. Buchman, V. Bottino-Rojas, A. A. James, M. W. Perry, G. Dimopoulos, O. Akbari

This paper develops a CRISPRa system in Aedes aegypti to transactivate endogenous genes, demonstrating its ability to overexpress developmental genes and suppress dengue virus.

bioRxiv · Aug 31, 2022Bioengineering

Engineered Reproductively Isolated Species Drive Reversible Population Replacement

A. Buchman, I. Shriner, T. Yang, J. Liu, I. Antoshechkin, J. M. Marshall, M. W. Perry, O. S. Akbari

The paper engineers reproductively isolated species using CRISPR to create threshold-dependent gene drive capabilities in D. melanogaster.

bioRxiv · Aug 9, 2020Bioengineering

Programmable RNA Targeting using CasRx in Flies

A. Buchman, D. J. Brogan, R. Sun, T. Yang, P. Hsu, O. Akbari

This study evaluates the use of CasRx, a Cas ribonuclease, for programmable RNA targeting in Drosophila melanogaster, showing transcript targeting, toxicity, and off-target effects.

bioRxiv · Apr 3, 2020Bioengineering

Broad Dengue Neutralization in Mosquitoes Expressing an Engineered Antibody

A. Buchman, S. Gamez, M. Li, I. Antoshechkin, S.-H. Lee, S.-W. Wang, C.-H. Chen, M. J. Klein, J.-B. Duchemin, J. E. Crowe, P. N. Paradkar, O. Akbari

This paper develops genetically engineered Aedes aegypti mosquitoes expressing an engineered antibody that broadly neutralizes all four DENV serotypes, significantly reducing viral transmission.

bioRxiv · May 24, 2019Bioengineering

Overcoming evolved resistance to population-suppressing homing-based gene drives

J. Marshall, A. Buchman, H. M. Sanchez C., O. S. Akbari

This paper develops a mathematical model to assess resistance to CRISPR-Cas9 homing gene drives and proposes a multiplexed gRNA strategy to enhance suppression efficacy.

bioRxiv · Dec 7, 2016Evolutionary Biology