L. C. Cantley

This study identifies vitcylation, a novel vitamin C-derived protein modification, and shows it enhances STAT1-mediated immune response by inhibiting PTPN2 interaction and increasing IFN pathway activation in tumor cells.

The paper models histological transformation of lung cancer and identifies neuroendocrine-specific tolerance to Myc as an oncogenic driver.

The paper shows that obesity increases DNA damage in breast epithelium of BRCA mutation carriers and suggests targeting estrogen or metabolic dysfunction may reduce breast cancer risk.

The paper identifies Hippo kinases as inhibitors of PI3K alpha, showing epinephrine activates these kinases to suppress insulin signaling and glucose metabolism.

The paper examines how SARS-CoV-2 variants interact with host proteases and shows that some proteases remain effective against variant spike proteins.

This study identifies NAP1 as a critical regulator of TBK1 activation at centrosomes during mitosis and cytokinesis, revealing its role in cell division through substrate interactions and degradation.

This study identifies a metabolic divergence between human and mouse lung adenocarcinomas due to LKB1-dependent regulation of TPI1 phosphorylation, highlighting limitations of mouse models for studying human cancer.

This study identifies p38β as a critical host factor for SARS-CoV-2 replication and shows that inhibiting it reduces viral replication and cytokine production.

The paper investigates the role of pyruvate kinase isoforms in prostate cancer, finding that Pkm1 suppresses cancer while Pkm2 promotes it, and that a PKM1-like activator can suppress tumor progression.

The paper compares two HTP methods, finding that LFE-HTP improves proteoform coverage and detects novel phosphorylation sites affecting protein stability.

This study shows coagulation factors like factor Xa and thrombin directly cleave SARS-CoV-2 spike, enhancing viral entry, and suggests anticoagulation could reduce infection.

The paper shows that methylmalonic acid accumulation with age promotes tumor progression by inducing SOX4 and reprogramming cancer cells.

This study uses hPSC-derived lung organoids to identify FDA-approved drugs that inhibit SARS-CoV-2 entry and reduce infection in a model of human COVID-19.

This study shows that brain metastases rely on PHGDH-mediated serine synthesis due to limited environmental serine, making them sensitive to PHGDH inhibition.

The paper shows that pancreatic ductal adenocarcinoma (PDA) is more dependent on GOT1 than colorectal cancer (CRC) and that GOT1 inhibition synergizes with radiotherapy to inhibit PDA growth.

This study identifies THZ-P1-2, a covalent pan-PI5P4K inhibitor, showing efficacy in AML/ALL cell lines and autophagy disruption, supporting PI5P4Ks as therapeutic targets in cancer.

This study shows that PIP4Ks suppress insulin signaling through a non-catalytic mechanism by regulating PIP5K activity and PI(4,5)P2 levels.