M. Morris

Discovery of active mouse, plant and fungal cytochrome P450s in endogenous proteomes and upon expression in planta.

The paper identifies active cytochrome P450s in mouse, plant, and fungal systems using chemical probes and mass spectrometry, showing their subcellular localization and activity-based labeling.

Genome evolution is surprisingly predictable after initial hybridization

The paper shows that local ancestry in hybrid swordtail fish populations is repeatable due to strong early selection, and this repeatability increases with deeper evolutionary divergence.

Renal Angptl4 is a key fibrogenic molecule in progressive diabetic kidney disease

This study identifies Angptl4 as a fibrogenic molecule in diabetic kidney disease and shows that targeting its expression in kidneys reduces fibrosis and proteinuria.

"Tranq-Dope" Overdose and Mortality: Lethality Induced by Fentanyl and Xylazine

This study quantifies the lethal effects of fentanyl-xylazine combinations in mice and shows naloxone can reduce lethality.

Recurrent evolution of small body size and loss of the sword ornament in Northern Swordtail fish

The paper uses whole-genome sequencing to resolve phylogenetic relationships in Xiphophorus fish, revealing recurrent loss of sexually selected traits like body size and sword ornaments.

Genomic characterization of metastatic patterns from prospective clinical sequencing of 25,000 patients

The paper analyzes genomic data from 25,000 patients to identify associations between genomic alterations and metastatic patterns across 50 tumor types, finding chromosomal instability correlates with metastatic burden in some cancers.

A novel drug-combination screen in zebrafish identifies epigenetic small molecule candidates for Duchenne muscular dystrophy

The paper identifies two epigenetic small molecules, oxamflatin and salermide, that improve skeletal muscle structure in zebrafish models of Duchenne muscular dystrophy through a drug-combination screen.

Genetic signature of prostate cancer resistant to optimized hK2 targeted alpha-particle therapy

The paper evaluates enhanced alpha-radioimmunotherapy for prostate cancer using [225Ac]hu11B6-IgG3 and analyzes genomic changes in resistant tumors.

Abnormalities in Proinsulin Processing in Islets from Individuals with Longstanding T1D

The paper investigates proinsulin processing abnormalities in T1D islets, finding reduced processing enzymes and cytokine-induced expression changes.