G. Larson

The importance of small island populations for the long term survival of endangered large-bodied insular mammals

This study shows that small island populations of anoa and babirusa have higher genetic quality despite lower diversity, suggesting they should be prioritized for conservation over mainland translocations.

Imputation of ancient canid genomes reveals inbreeding history over the past 10,000 years

This study imputes ancient dog and wolf genomes to analyze inbreeding history over 10,000 years, finding lower inbreeding in ancient populations and associations between low ROH regions and olfaction/immune genes.

Unraveling the Global Proteome and Phosphoproteome of Prostate Cancer Patient-Derived Xenografts

The paper characterizes the proteome and phosphoproteome of prostate cancer patient-derived xenografts to identify differences between neuroendocrine-like and adenocarcinoma subtypes.

Understanding ATP binding to DosS catalytic domain with a short ATP-lid

This paper investigates ATP binding in the short ATP-lid of DosS CA domain, showing it binds ATP under physiological conditions and revealing conformational flexibility affected by zinc concentration.

Differential neutralization and inhibition of SARS-CoV-2 variants by antibodies elicited by COVID-19 mRNA vaccines

This study evaluates how well antibodies from mRNA vaccines neutralize SARS-CoV-2 variants, finding that Omicron shows the most escape but booster doses maintain moderate neutralizing activity.

Extracellular endosulfatase Sulf-2 harbours a chondroitin/dermatan sulfate chain that modulates its enzyme activity

This study identifies a chondroitin/dermatan sulfate chain in Sulf-2 that modulates its enzyme activity, revealing a new paradigm for Sulfs' function.

SARS-CoV-2 susceptibility of cell lines and substrates commonly used in diagnosis and isolation of influenza and other viruses

This study evaluates SARS-CoV-2 susceptibility in cell lines used for influenza and other virus diagnosis, finding that some are permissive while others are not, with MDCK cells being insusceptible due to low ACE2 expression.

Revealing interspecies transmission barriers of avian influenza A viruses

This study investigates interspecies transmission barriers of avian influenza A viruses by analyzing infection dynamics, receptor expression, and host responses in different avian hosts.

Chondroitin sulfate proteoglycan Windpipe modulates Hedgehog signaling in Drosophila

This study identifies Windpipe as a chondroitin sulfate proteoglycan that modulates Hedgehog signaling in Drosophila by regulating Smoothened stability.

Modern wolves trace their origin to a late Pleistocene expansion from Beringia

This study traces the origin of modern wolves to a late Pleistocene expansion from Beringia, using ancient mitochondrial genomes and spatial-temporal modeling.

Selection of appropriate metagenome taxonomic classifiers for ancient microbiome research

This study evaluates how ancient DNA damage affects taxonomic classification accuracy in metagenomic datasets using five classifiers, finding that program-specific biases outweigh damage effects.

Synchronous diversification of Sulawesi’s iconic artiodactyls driven by recent geological events

The paper tests the hypothesis that recent geological events on Sulawesi drove the synchronous diversification of its endemic artiodactyls, finding that species expanded from a central area that emerged above sea level ~1-2 Myr ago.

The dental calculus metabolome in modern and historic samples

This study characterizes the metabolome of modern and historic dental calculus to identify patterns of metabolite persistence and loss over time.