Author
Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.
8 papers
Recent·Most cited
F. Pinilla, J. Soto, P. E. Olguin, L. E. Castaneda
This study investigates the genetic basis of thermal tolerance in Drosophila melanogaster using the DGRP, identifying heritable variation and genetic associations with heat tolerance parameters.
bioRxiv · Jul 1, 2024 · PreprintEvolutionary Biology
Y. Wu, Y. Song, J. Soto, T. Hoffman, X. Lin, A. Zhang, S. Chen, R. N. Massad, X. Han, D. Qi, K.-W. Yeh, Z. Fang, J. Eoh, L. Gu, A. C. Rowat, , S. Li
This study shows viscoelastic substrates enhance epigenetic remodeling and cellular plasticity in fibroblasts, improving reprogramming efficiency into neurons and pluripotent stem cells.
bioRxiv · Apr 14, 2024Cell Biology
E. E. Ford, D. Tieri, O. L. Rodriguez, N. J. Francoeur, J. Soto, J. T. Kos, A. Peres, W. S. Gibson, C. A. Silver, G. Deikus, E. Hudson, C. R. Woolley, N. Beckmann, A. Charney, T. C. Mitchell, , M. L. Smith
FLAIRR-seq provides high-resolution, single-molecule characterization of immunoglobulin heavy chain repertoires, including constant region features, and identifies novel alleles.
bioRxiv · Sep 24, 2022 · PreprintImmunology
Y. Song, J. Soto, B. Chen, W. Zhao, T. Hoffman, N. Zhu, Q. Peng, C. Ly, P. K. Wong, Y. Wang, A. C. Rowat, S. K. Kurdistani, S. Li
This study shows that transient nuclear deformation enhances cell reprogramming by altering epigenetic states, specifically reducing DNA methylation and H3K9 methylation.
bioRxiv · May 19, 2021Biophysics
C. L. Moody, J. Soto, V. Tretyachenko-Ladokhina, D. F. Senear, M. J. Cocco
This study examines how the CytR DNA-binding domain interacts with different DNA substrates, revealing structural and dynamic changes upon specific versus nonspecific binding.
bioRxiv · Feb 28, 2021 · PreprintBiophysics
J. Soto, C. Moody, A. Alhoshani, M. Sanchez-Bonilla, D. Martinon, M. J. Cocco
This paper uses NMR to show that rescue mutants N235K and N239Y stabilize p53 by altering protein dynamics, with distinct effects on different regions of the DNA binding domain.
bioRxiv · Feb 26, 2021 · PreprintBiophysics
E. P. Barros, O. Demir, J. Soto, M. J. Cocco, R. E. Amaro
The paper uses Markov state models and NMR to study p53 mutations, revealing a previously overlooked allosteric loop involved in conformational dynamics and mutation-induced inactivation.
bioRxiv · Oct 19, 2020Biophysics
A. Mansilla, J. Soto, C. Henriquez, A. R. Philp, M. A. Mall, J. Sarmiento, C. A. Flores
This study shows tamoxifen reduces neutrophil infiltration in inflamed airways across multiple mouse models without affecting mucociliary clearance.
bioRxiv · Jun 19, 2020 · PreprintPharmacology & Toxicology