Author

T. Hoffman

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Assay:ATAC-seq· 2 Research Focus:cell type annotation· 2 Approach:experimental assay· 2 Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:development & morphogenesis· 1

Frequent Co-Authors

A. C. Rowat· 2 shared J. Soto· 2 shared S. Li· 2 shared Y. Song· 2 shared A. Zhang· 1 shared B. Chen· 1 shared C. Ly· 1 shared D. Qi· 1 shared

Activity by Year

2021-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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2 shared papersCell Biology

A. C. Rowat

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2 papers

Recent·Most cited

Viscoelastic Extracellular Matrix Enhances Epigenetic Remodeling and Cellular Plasticity

Y. Wu, Y. Song, J. Soto, T. Hoffman, X. Lin, A. Zhang, S. Chen, R. N. Massad, X. Han, D. Qi, K.-W. Yeh, Z. Fang, J. Eoh, L. Gu, A. C. Rowat, , S. Li

This study shows viscoelastic substrates enhance epigenetic remodeling and cellular plasticity in fibroblasts, improving reprogramming efficiency into neurons and pluripotent stem cells.

bioRxiv · Apr 14, 2024Cell Biology

Transient nuclear deformation primes epigenetic state and promotes cell reprogramming

Y. Song, J. Soto, B. Chen, W. Zhao, T. Hoffman, N. Zhu, Q. Peng, C. Ly, P. K. Wong, Y. Wang, A. C. Rowat, S. K. Kurdistani, S. Li

This study shows that transient nuclear deformation enhances cell reprogramming by altering epigenetic states, specifically reducing DNA methylation and H3K9 methylation.

bioRxiv · May 19, 2021Biophysics