J. Straube

Imetelstat-Mediated Alterations in Fatty Acid Metabolism To Induce Ferroptosis As Therapeutic Strategy for Acute Myeloid Leukemia

This study identifies ferroptosis as a mechanism by which imetelstat induces therapeutic effects in AML, showing that targeting fatty acid metabolism enhances its efficacy.

CD4+ T cells display a spectrum of recall dynamics during re-infection with malaria parasites.

This study examines CD4+ T cell recall dynamics during Plasmodium re-infection in mice, revealing a spectrum of responses including refractory GC Tfh cells, rapid Th1-memory responses, and a partial facsimile of primary Th1 responses.

Oncogenic drivers dictate immune control of acute myeloid leukemia.

This study shows that specific AML oncogenes influence immune responses and escape mechanisms, with NrasG12D promoting anti-leukemia immunity that can be counteracted by Myc.

An inosine triphosphate pyrophosphatase safeguards nucleic acids from aberrant purine nucleotides

This study identifies ITPA as a plant enzyme that prevents the accumulation of aberrant purine nucleotides in nucleic acids, thereby avoiding stress responses and premature senescence.

Expression of CD49f defines subsets of human regulatory T cells with divergent transcriptional landscape and function that correlate with ulcerative colitis disease activity

The paper identifies CD49f-expressing subsets of human regulatory T cells with distinct transcriptional profiles and functions linked to ulcerative colitis disease activity.

Transcriptome Dynamics Reveals Progressive Transition from Effector to Memory in CD4+ T cells.

This study uses single-cell RNA-seq and ATAC-seq to show a progressive transition from effector to memory CD4+ T cells during Plasmodium infection, with linear pathways and memory-associated gene expression.