M. Braun

Type I interferon drives a cellular state inert to TCR-stimulation and could impede effective T-cell differentiation in cancer

The paper identifies a subset of CD8+ TILs in HPV-HNSCC enriched for interferon-stimulated genes that are transcriptionally inert to TCR stimulation and may hinder T-cell differentiation.

Tau phosphorylation impedes functionality of protective tau envelopes

This study shows that tau phosphorylation impairs the protective function of tau envelopes, leading to microtubule destabilization in neurodegenerative disorders.

The microbiome of the lichen Lobaria pulmonaria varies according to climate in Europe

This study examines how the bacterial microbiome of the lichen Lobaria pulmonaria varies with climate across Europe, finding that climatic factors explain more variation than local weather or sampling season.

NF1 modulates microtubule repair and sensitivity to antibody-drug conjugates

This study shows that NF1 loss increases sensitivity to the ADC T-DM1 by modulating microtubule repair and dynamics, identifying NF1 as a predictive biomarker for ADC response.

Microtubules under mechanical pressure can breach dense actin networks

The paper shows microtubules can breach dense actin networks under mechanical pressure when immobilized.

Oncogenic drivers dictate immune control of acute myeloid leukemia.

This study shows that specific AML oncogenes influence immune responses and escape mechanisms, with NrasG12D promoting anti-leukemia immunity that can be counteracted by Myc.

A Physcomitrella PIN protein acts in spermatogenesis and sporophyte retention

This study investigates the role of PpPINC in Physcomitrella, showing its importance in spermatogenesis and sporophyte retention through genetic and transcriptomic analyses.

Shallow nanopore RNA sequencing enables transcriptome profiling for precision cancer medicine

This study evaluates shallow nanopore RNA sequencing for transcriptome profiling in cancer, showing it is rapid, cost-effective, and comparable to Illumina for key analyses.

Microtubule Lattice Spacing Governs Cohesive Envelope Formation of Tau Family Proteins

This study shows that tau family proteins form cohesive envelopes around microtubules, regulated by lattice spacing, which differentially affects motor protein movement and microtubule function.

A chemical screen for suppressors of dioxygenase inhibition in a yeast model of familial paraganglioma

The paper identifies meclofenoxate HCL and DMAE as suppressors of dioxygenase inhibition in a yeast model of SDH loss by normalizing the succinate:2-ketoglutarate ratio.

Membrane fission during bacterial spore development requires DNA-pumping driven cellular inflation

This study shows that DNA-pumping driven forespore inflation generates membrane tension required for FisB-mediated membrane fission during bacterial spore development.

Fast leaps between millisecond confinements govern Ase1 diffusion along microtubules

The paper visualizes Ase1 diffusion along microtubules, revealing millisecond confinements and fast leaps between them, matching the tubulin-dimer periodicity.

Temperature Dependence of the Krokinobacter rhodopsin 2 Kinetics

This study analyzes temperature-dependent kinetics of Krokinobacter rhodopsin 2 using flash photolysis and kinetic modeling to reveal how different photocycle steps respond to temperature changes.

Nanoscopic Structural Fluctuations of Disassembling Microtubules Revealed by Label-Free Super-Resolution Microscopy

This study uses label-free super-resolution microscopy to observe nanoscopic structural changes during microtubule disassembly, revealing discrete transitions and pauses in the process.

FisB relies on homo-oligomerization and lipid-binding to catalyze membrane fission in bacteria

This study identifies that FisB catalyzes bacterial membrane fission through homo-oligomerization and lipid-binding, without requiring curvature sensing or lipid microdomains.

The anticipated potential nuclear localization sequence of 'Candidatus Phytoplasma mali SAP11-like protein is required for TCP binding but not for transport into the nucleus

The study identifies a nuclear localization sequence in the SAP11-like protein of Ca. P. mali that is essential for TCP binding but not for nuclear transport.

Intrinsically disordered domain of kinesin-3 Kif14 enables unique functional diversity

This study identifies the intrinsically disordered N-terminal domain of Kif14 as enabling its unique functional diversity through enhanced microtubule interactions and processivity.

Mitochondria-adaptor TRAK1 promotes kinesin-1 driven transport in crowded environments

This study shows TRAK1 enhances kinesin-1 transport efficiency in crowded environments by enabling obstacle navigation and increased run length.

Anillin propels myosin-independent constriction of actin rings

This study shows anillin drives myosin-independent actin ring constriction by generating forces that maximize filament overlap.

A large self-transmissible plasmid from Nigeria confers resistance to multiple antibacterials without a carrying cost

Kinetically distinct phases of tau on microtubules regulate kinesin motors and severing enzymes

This study shows tau forms distinct kinetic phases on microtubules that regulate kinesin motors and severing enzymes like katanin.

Local Nucleation Of Microtubule Bundles Through Tubulin Concentration Into A Condensed Tau Phase

The paper shows that tau forms liquid droplets that concentrate tubulin, enabling local microtubule bundle nucleation without centrosomes.