Author

K. L. Hoffman

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 7 Animal Behavior & Cognition· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Organism:human· 5 Assay:bulk RNA-seq· 4 Research Focus:cell type annotation· 4 Research Focus:differential expression· 4 Research Focus:host-pathogen & immune response· 3 Approach:statistical model· 3 Assay:whole-genome sequencing· 3

Frequent Co-Authors

H. Doddapaneni· 5 shared J. F. Petrosino· 5 shared V. K. Menon· 5 shared A. Rajan· 4 shared D. M. Muzny· 4 shared R. A. Gibbs· 4 shared S. J. Javornik Cregeen· 4 shared G. Metcalf· 3 shared

Activity by Year

2020-2023 · peak 5/yr

Co-Author Collaboration Network

10 top collaborators · 44 mutual co-author links

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5 shared papersMicrobiology

H. Doddapaneni

Mutual co-authors in cluster

Author profile →

9 papers

Recent·Most cited

Tryptophan Metabolites And Their Predicted Microbial Sources In Fecal Samples From Healthy Individuals

C. L. Chappell, K. L. Hoffman, P. L. Lorenzi, L. Tan, J. Petrosino, R. Gibbs, D. Muzny, H. Doddapaneni, M. C. Ross, V. K. Menon, A. Surathu, S. J. Javornik Cregeen, A. G. Reyes, P. C. Okhuysen

The paper measures tryptophan metabolites in fecal samples from healthy individuals and links them to bacterial abundance and predicted microbial sources.

bioRxiv · Dec 20, 2023 · PreprintMicrobiology

Phage-bacteria dynamics during the first years of life revealed by trans-kingdom marker gene analysis

M. J. Tisza, R. E. Lloyd, K. L. Hoffman, D. P. Smith, M. Rewers, the TEDDY Study Group, S. J. J. Cregeen, J. F. Petrosino

This study analyzes phage and bacterial dynamics in early human life using longitudinal data from the TEDDY study, revealing individual-specific phage communities and ecological patterns correlated with bacterial hosts.

bioRxiv · Sep 28, 2023 · PreprintMicrobiology

Functional Genomics of Gastrointestinal Escherichia coli Isolated from Patients with Cancer and Diarrhea

H. Carter, J. Clark, L. G. Carlin, E. Vaughan, A. Rajan, A. Olvera, X. Yu, X.-L. Zeng, A. Kambal, M. Holder, X. Qin, R. A. Gibbs, J. F. Petrosino, D. M. Muzny, H. Doddapaneni, , P. C. Okhuysen

The paper investigates E. coli strains from cancer patients with diarrhea, finding novel adherence patterns and high antibiotic resistance gene carriage.

bioRxiv · May 31, 2023 · PreprintMicrobiology

Intra- and Inter-host Evolution of Human Norovirus in Healthy Adults

S. Ramani, S. J. Javornik Cregeen, A. Surathu, F. H. Neill, D. M. Muzny, H. Doddapaneni, V. K. Menon, K. L. Hoffman, M. C. Ross, G. Metcalf, A. R. Opekun, D. Y. Graham, R. A. Gibbs, J. F. Petrosino, M. K. Estes, R. L. Atmar

The paper studies intra- and inter-host evolution of human norovirus in healthy adults using a capture-based sequencing approach, finding limited conserved immune pressure-driven evolution.

bioRxiv · May 30, 2023 · PreprintMicrobiology

Longitudinal host transcriptional responses to SARS-CoV-2 infection in adults with extremely high viral load

V. Avadhanula, C. J. Creighton, L. Ferlic-Stark, R. Sucgang, Y. Zhang, D. Nagaraj, E. G. Nicholson, A. Rajan, V. K. Menon, H. Doddapaneni, D. M. Muzny, G. A. Metcalf, S. J. J. Cregeen, K. L. Hoffman, R. A. Gibbs, , P. A. Piedra

The paper examines longitudinal transcriptional responses to SARS-CoV-2 infection in adults with varying viral loads, identifying gene expression patterns and host responses over time.

bioRxiv · May 24, 2023Microbiology

Dose-dependent dissociation of pro-cognitive effects of donepezil on attention and cognitive flexibility in rhesus monkeys

S. A. Hassani, S. Lendor, A. Neumann, K. S. Roy, K. Banaie Boroujeni, K. L. Hoffman, J. Pawliszyn, T. Womelsdorf

This study shows that different doses of donepezil affect attention and cognitive flexibility differently in rhesus monkeys, with higher doses improving attention but not flexibility.

bioRxiv · Aug 9, 2021Pharmacology & Toxicology

Multiple RSV strains infecting HEp-2 and A549 cells reveal cell line-dependent differences in resistance to RSV infection.

A. Rajan, F.-A. Piedra, L. Aideyan, T. McBride, M. J. Robertson, H. L. Johnson, G. M. Aloisio, D. M. Henke, C. Coarfa, F. Stossi, V. K. Menon, H. Doddapaneni, D. Muzny, S. J. Javornik Cregeen, K. L. Hoffman, , P. A. Piedra

The paper compares RSV infection in HEp-2 and A549 cells using four strains, finding subgroup-dependent gene expression differences and A549's greater antiviral response.

bioRxiv · Jun 15, 2021 · PreprintMicrobiology

A Kiosk Station for the Assessment of Multiple Cognitive Domains and Enrichment of Monkeys

T. Womelsdorf, C. Thomas, A. Neumann, M. Watson, K. Banaie Boroujeni, S. A. Hassani, J. M. Parker, K. L. Hoffman

This paper introduces a Kiosk Station for running cognitive tasks in cage-housed monkeys, showing high engagement and consistency in cognitive performance.

bioRxiv · Mar 6, 2021Animal Behavior & Cognition

Oligonucleotide capture sequencing of the SARS-CoV-2 genome and subgenomic fragments from COVID-19 individuals

H. V. Doddapaneni, S. J. Cregeen, R. Sucgang, Q. Meng, X. Qing, V. Avadhanula, H. Chao, V. Menon, E. Nicholson, D. Henke, F.-A. Piedra, A. Rajan, Z. Momin, K. Kottapalli, K. L. Hoffman, , R. A. Gibbs

This study develops an oligonucleotide capture sequencing method to generate SARS-CoV-2 genomic and transcriptome sequences from clinical samples, revealing differential transcriptional activity and ORF10 expression.

bioRxiv · Jul 27, 2020 · PreprintMicrobiology