Q. Meng

Calorie Restriction Induces Degeneration of Neurons with Mitochondrial DNA Depletion by Altering ER-Mitochondria Calcium Transfer

This study shows that calorie restriction exacerbates neuronal degeneration in mtDNA-depleted neurons by increasing ER-mitochondria calcium transfer, suggesting CR may not be beneficial for mitochondrial epilepsy.

Time-lapse Image Super-resolution Neural Network with Reliable Confidence Quantification for Optical Microscopy

This paper introduces a time-lapse image super-resolution neural network with confidence quantification for optical microscopy, improving temporal consistency and reliability.

Targeting CD19 for the treatment of autoimmune with a novel T cell engager

This study develops YK012, a T cell engager targeting CD19, showing potential for treating autoimmune diseases with improved efficacy and reduced side effects compared to existing therapies.

CCT3 drives Sorafenib resistance by inhibiting TFRC-mediated iron uptake in HCC

This study identifies CCT3 as a driver of Sorafenib resistance in HCC by inhibiting TFRC-mediated iron uptake, leading to ferroptosis resistance.

Functional Genomics of Gastrointestinal Escherichia coli Isolated from Patients with Cancer and Diarrhea

The paper investigates E. coli strains from cancer patients with diarrhea, finding novel adherence patterns and high antibiotic resistance gene carriage.

A novel bacterial signal transduction system specifically senses and responds to peptidoglycan damage

This study identifies a bacterial two-component system that detects and responds to peptidoglycan damage, revealing its role in antibiotic resistance and tolerance.

Self-supervised denoising for structured illumination microscopy enables long-term super-resolution live-cell imaging

The paper introduces a self-supervised denoising method for structured illumination microscopy that enables high-quality super-resolution imaging with reduced fluorescence.

Zero-shot learning enables instant denoising and super-resolution in optical fluorescence microscopy

This paper introduces a zero-shot deep learning method for super-resolution microscopy that enhances resolution with less fluorescence and no training data.

Cardiac fibroblasts regulate cardiomyocyte hypertrophy through dynamic regulation of type I collagen

This study shows that type I collagen produced by cardiac fibroblasts regulates cardiomyocyte hypertrophy and fibrosis, with developmental and acute deletion effects on cardiac function.

The Impact of a Dynamic Working Environment on Human Gut Microbiota

This study compares gut microbiota composition between officials in a stable environment and train drivers in a dynamic environment, finding differences in diversity and functional predictions.

Functional tagging of endogenous proteins and rapid selection of cell pools (Rapid generation of endogenously tagged piwi in ovarian somatic sheath cells.)

The paper presents a method to generate stable, endogenously tagged alleles in non-transformed cells, demonstrating its application in Drosophila ovarian somatic sheath cells for functional studies of Piwi.

Clonal expansion of personalized anti-tumor T cells from circulation using tumor organoid-immune co-cultures

This study expands tumor-specific T cells from pancreatic cancer patients' blood using tumor organoid-immune co-cultures and identifies patient-specific TCRs for immunotherapy.

A quasi-paired cohort strategy reveals the impaired detoxifying function of microbes in the gut of autistic children

This study identifies impaired microbial detoxification in autistic children using a quasi-paired cohort strategy, linking it to mitochondrial damage and potential therapeutic strategies.

Oligonucleotide capture sequencing of the SARS-CoV-2 genome and subgenomic fragments from COVID-19 individuals

This study develops an oligonucleotide capture sequencing method to generate SARS-CoV-2 genomic and transcriptome sequences from clinical samples, revealing differential transcriptional activity and ORF10 expression.

SARS-CoV-2 envelope protein causes acute respiratory distress syndrome (ARDS)-like pathological damage and constitutes an antiviral target

This study shows the SARS-CoV-2 envelope protein causes ARDS-like damage and identifies channel inhibitors as potential antiviral targets.

Identification of PDE6D as a potential target of sorafenib via PROTAC technology

This study identifies PDE6D as a potential target of sorafenib using PROTAC technology and proteomic analysis.

Angle-tuned Coil: A Focal Spot-size Adjustable Transcranial Magnetic Stimulator

This paper introduces a new transcranial magnetic stimulator coil design that improves depth-focality tradeoff and allows adjustable focal spot size for deep brain stimulation.

Stromal ISLR promotes intestinal regeneration and cancer by suppressing epithelial Hippo signaling

This study identifies ISLR as a stromal factor that suppresses epithelial Hippo signaling to promote intestinal regeneration and cancer.

Comprehensive proteomic and metabolomic profiling of mcr-1 mediated colistin resistance in Escherichia coli

This study identifies proteomic and metabolomic changes in Escherichia coli mediated by mcr-1, showing altered lipid metabolism and efflux pump activity contribute to colistin resistance.