Author

K. McCortney

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 5

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 3 Research Focus:cancer & tumor microenvironment· 3 Organism:human· 3 Approach:experimental assay· 2 Organism:mouse· 2 Research Focus:cell type annotation· 1 Approach:deep learning· 1 Research Focus:differential expression· 1

Frequent Co-Authors

C. Horbinski· 5 shared A. Steffens· 3 shared A. Lauko· 2 shared M. Drumm· 2 shared A. Golebiewska· 1 shared A. Kreshuk· 1 shared A. Rabljenovic· 1 shared A. Sonabend· 1 shared

Activity by Year

2021-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 23 mutual co-author links

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5 shared papersCancer Biology

C. Horbinski

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Author profile →

5 papers

Recent·Most cited

Deep intravital brain tumor imaging enabled by tailored three-photon microscopy and analysis

M. C. Schubert, S. J. Soyka, A. Tamimi, E. Maus, R. Denninger, N. Wissmann, E. Reyhan, S. K. Tetzlaff, C. Beretta, M. Drumm, J. Schroers, A. Steffens, J. Walshon, K. McCortney, S. Heiland, , V. Venkataramani

This paper introduces Deep3P, a three-photon microscopy and AI analysis method that enables deep intravital imaging of glioblastoma in mouse brains, revealing new insights into tumor invasion routes and white matter disruption.

bioRxiv · Jun 17, 2023Cancer Biology

The MIF SNP rs755622 is a germline determinant of tumor immune activation in Glioblastoma

T. Alban, M. M. Grabowski, B. Otvos, D. B. Watson, A. Zalavadia, V. Makarav, K. M. Troike, M. McGraw, A. Rabljenovic, A. Lauko, C. K. A. Neumann, G. Roversi, K. Waite, G. Cioffi, N. Patil, , J. Lathia

The paper identifies a germline SNP, rs755622, associated with increased leukocyte infiltration in glioblastoma and links it to lactotransferrin expression as a potential biomarker for immune activation.

bioRxiv · Mar 7, 2022 · PreprintCancer Biology

SerpinB3 drives cancer stem cell survival in glioblastoma

A. Lauko, J. Volovetz, S. M. Turaga, D. Bayik, D. C. Watson, D. J. Silver, K. Mitchell, E. Mulkearns-Hubert, K. Desai, M. Midha, J. Hao, K. McCortney, A. Steffens, U. Naik, M. S. Ahluwalia, , J. D. Lathia

This study identifies SerpinB3 as a key driver of glioblastoma cancer stem cell survival and shows that targeting it enhances radiation therapy efficacy in pre-clinical models.

bioRxiv · Dec 21, 2021Cancer Biology

The efficacy of a ketogenic diet in preclinical models of IDH wild-type and IDH mutant glioma

R. Javier, W. Wang, M. Drumm, K. McCortney, J. N. Sarkaria, C. Horbinski

This study evaluates the efficacy of a ketogenic diet in preclinical models of IDH wild-type and IDH mutant gliomas, finding no significant effect on tumor growth or survival.

bioRxiv · Sep 9, 2021Cancer Biology

CRISPR-Cas9 Screen Reveals PSMB3 Contributes to Gliomagenesis Through Proteasome-Dependent and Independent Mechanisms

S. Baisiwala, S. Budhiraja, A. Zolp, K. Nandoliya, L. Chen, C. Park, E. Perrault, M. Saathoff, C. Dmello, J. Shireman, P. Lin, G. Dara, K. McCortney, C. Horbinski, A. Sonabend, A. U. Ahmed

The paper identifies PSMB3 as a contributor to gliomagenesis through proteasome-dependent and independent mechanisms using a CRISPR-Cas9 screen in GBM.

bioRxiv · Jul 28, 2021 · PreprintCancer Biology