Author

D. C. Watson

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Immunology· 2

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 3 Research Focus:cancer & tumor microenvironment· 3 Approach:experimental assay· 3 Organism:human· 2 Organism:mouse· 2 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

D. Bayik· 4 shared A. Lauko· 3 shared D. J. Silver· 3 shared J. D. Lathia· 3 shared M. S. Ahluwalia· 3 shared F. Cheng· 2 shared M. McGraw· 2 shared Y. Zhou· 2 shared

Activity by Year

2020-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

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4 shared papersImmunology

D. Bayik

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Sex-specific T cell exhaustion drives differential immune responses in glioblastoma

J. Lee, M. Nicosia, D. J. Silver, C. Li, D. Bayik, D. C. Watson, A. Lauko, S. Johnson, M. McGraw, M. Grabowski, D. Kish, A. Desai, W. Goodman, S. Cameron, H. Okada, , J. D. Lathia

This study shows male T cells are more exhausted in glioblastoma, leading to worse outcomes and better response to anti-PD1 treatment compared to females.

bioRxiv · Aug 17, 2022 · PreprintImmunology

SerpinB3 drives cancer stem cell survival in glioblastoma

A. Lauko, J. Volovetz, S. M. Turaga, D. Bayik, D. C. Watson, D. J. Silver, K. Mitchell, E. Mulkearns-Hubert, K. Desai, M. Midha, J. Hao, K. McCortney, A. Steffens, U. Naik, M. S. Ahluwalia, , J. D. Lathia

This study identifies SerpinB3 as a key driver of glioblastoma cancer stem cell survival and shows that targeting it enhances radiation therapy efficacy in pre-clinical models.

bioRxiv · Dec 21, 2021Cancer Biology

Horizontal mitochondrial transfer from the microenvironment increases glioblastoma tumorigenicity

D. C. Watson, D. Bayik, S. E. Williford, A. Lauko, Y. Zhou, G. Deshpande, J. Seder, J. A. Mears, F. Cheng, A. B. Hjelmeland, J. D. Lathia

The paper identifies horizontal mitochondrial transfer from astrocytes to glioblastoma cells as a mechanism that enhances tumorigenicity by improving mitochondrial function and metabolic capacity.

bioRxiv · Sep 1, 2021Cancer Biology

Myeloid-derived suppressor cell subsets drive glioblastoma growth in a sex-specific manner

D. Bayik, Y. Zhou, C. Park, C. Hong, D. Vail, D. J. Silver, A. J. Lauko, G. A. Roversi, D. C. Watson, A. Lo, T. J. Alban, M. McGraw, M. D. Sorensen, M. M. Grabowski, B. Otvos, , J. Lathia

This study identifies sex-specific roles of MDSC subsets in glioblastoma, showing mMDSCs drive growth in males and gMDSCs in females, with potential therapeutic targets.

bioRxiv · Feb 19, 2020Immunology