Author

K. Pollard

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 3 Microbiology· 2 Ecology· 1 Evolutionary Biology· 1

Signature Assays, Organisms & Methods

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Organism:human· 5 Approach:experimental assay· 4 Assay:bulk RNA-seq· 3 Assay:metagenomics· 3 Approach:statistical model· 3 Research Focus:cell type annotation· 2 Research Focus:clustering· 2 Research Focus:differential expression· 2

Frequent Co-Authors

C. A. Pratilas· 3 shared S. J. Gosline· 3 shared A. C. Hirbe· 2 shared D. A. Largaespada· 2 shared D. K. Wood· 2 shared E. Conniff· 2 shared J. C. Pino· 2 shared J. Wang· 2 shared

Activity by Year

2017-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

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3 shared papersCancer Biology

C. A. Pratilas

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Author profile →

7 papers

Recent·Most cited

Accurate estimation of intraspecific microbial gene content variation in metagenomic data with MIDAS v3 and StrainPGC

B. J. Smith, C. Zhao, V. Dubinkina, X. Jin, L. Zahavi, S. Shoer, J. Moltzau-Anderson, E. Segal, K. Pollard

The paper introduces StrainPGC and MIDAS v3 to accurately estimate intraspecific microbial gene content variation in metagenomic data, outperforming existing methods and revealing functional diversity in gut microbiomes.

bioRxiv · Apr 10, 2024Microbiology

CDK4/6 inhibition enhances SHP2 inhibitor efficacy and is dependent upon restoration of RB function in malignant peripheral nerve sheath tumors

J. Wang, A. Calizo, L. Zhang, J. C. Pino, Y. Lyu, K. Pollard, X. Zhang, A. T. Larsson, E. Conniff, N. Llosa, D. K. Wood, D. A. Largaespada, S. E. Moody, S. J. Gosline, A. C. Hirbe, C. A. Pratilas

This study shows that combining SHP2 inhibitor TNO155 with CDK4/6 inhibitor enhances anti-tumor activity in MPNST by restoring RB function and overcoming resistance.

bioRxiv · Feb 2, 2023Cancer Biology

mNGS Investigation of Single Ixodes pacificus Ticks Reveals Diverse Microbes, Viruses, and a Novel mRNA-like Endogenous Viral Elements

C. Martyn, B. Hayes, D. Lauko, E. Mithun, G. Castaneda, A. Bosco-Lauth, A. Kistler, K. Pollard, S. Chou

The paper uses metatranscriptomic analysis of Ixodes pacificus ticks to identify novel viruses and virus-like elements, revealing their potential roles in tick physiology and public health.

bioRxiv · Aug 17, 2022 · PreprintMicrobiology

Ex vivo to in vivo model of malignant peripheral nerve sheath tumors for precision oncology

H. Bhatia^, A. T. Larsson^, A. Calizo^, K. Pollard, X. Zhang, E. Conniff, J. F. Tibbitts, S. H. Osum, K. B. Williams, A. L. Crampton, T. Jubenville, D. Schefer, K. Yang, Y. Lyu, J. Bade, , A. C. Hirbe

The paper develops an ex vivo 3D microtissue model of MPNST that captures genomic diversity and predicts in vivo drug response.

bioRxiv · Apr 29, 2022 · PreprintCancer Biology

A clinically and genomically annotated nerve sheath tumor biospecimen repository.

K. Pollard, J. Banerjee, X. Doan, J. Wang, X. Guo, R. J. Allaway, S. Langmead, B. Slobogean, C. Meyer, D. Loeb, C. Morris, A. Belzberg, J. O. Blakeley, F. Rodriguez, J. Guinney, , C. A. Pratilas

The paper establishes a clinically and genomically annotated nerve sheath tumor biospecimen repository to support research on NF1-related tumors.

bioRxiv · Dec 19, 2019Cancer Biology

Global ecotypes in the ubiquitous marine clade SAR86

A. Hoarfrost, S. Nayfach, J. Ladau, S. Yooseph, C. Arnosti, C. L. Dupont, K. Pollard

The paper identifies five SAR86 gene clusters with distinct geographic distributions and environmental associations, revealing complex biogeography and functional specialization.

bioRxiv · May 10, 2019Ecology

Developmental loci harbor clusters of accelerated regions that evolved independently in ape lineages

D. Kostka, A. K. Holloway, K. Pollard

The paper identifies lineage-specific accelerated regions in ape genomes, showing similar patterns of accelerated evolution in developmental regulatory elements across multiple apes.

bioRxiv · Nov 28, 2017Evolutionary Biology