Author

K. Vickers

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioengineering· 2 Cell Biology· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:mouse· 3 Research Focus:cell type annotation· 2 Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:differential expression· 1

Frequent Co-Authors

C. Duvall· 2 shared D. L. Michell· 2 shared E. Hoogenboezem· 2 shared N. Francini· 2 shared R. Allen· 2 shared A. Abdulrahman· 1 shared A. Cavnar· 1 shared A. Eastman· 1 shared

Activity by Year

2019-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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2 shared papersBioengineering

C. Duvall

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Lipid-siRNA conjugate accesses a perivascular transport mechanism and achieves widespread and durable knockdown in the central nervous system

A. Sorets, K. Schwensen, N. Francini, A. Kjar, A. Abdulrahman, A. Shostak, K. Katdare, K. Schoch, R. Cowell, J. Park, A. Ligocki, W. Ford, L. Ventura-Antunes, E. Hoogenboezem, A. Prusky, , E. Lippmann

This study develops a lipid-siRNA conjugate that uses perivascular transport to achieve long-lasting gene knockdown in the CNS without toxicity.

bioRxiv · Jun 9, 2024 · PreprintBioengineering

Structural Optimization of siRNA Conjugates for Albumin Binding Achieves Effective MCL1-Targeted Cancer Therapy

E. Hoogenboezem, S. S. Patel, A. Cavnar, J. Lo, L. Babb, N. Francini, P. Patil, J. Colazo, D. L. Michell, V. Sanchez, J. McCune, J. Ma, C. DeJulius, L. Lee, J. Rosch, , C. Duvall

This paper optimizes siRNA conjugates for albumin binding to enhance tumor delivery and efficacy in cancer therapy, achieving 80% MCL1 silencing and improved survival in breast cancer models.

bioRxiv · Feb 14, 2023 · PreprintBioengineering

Biogenesis of RNA-containing extracellular vesicles at endoplasmic reticulum membrane contact sites

B. Barman, J. Ping, E. Krystofiak, R. Allen, N. Prasad, K. Vickers, J. G. Patton, Q. Liu, A. M. Weaver

This study identifies VAP-A as a key regulator of RNA-containing extracellular vesicle biogenesis and shows its role in miR-100 transfer and tumor formation.

bioRxiv · Dec 4, 2020 · PreprintCell Biology

Palmitate induces apoptotic cell death and inflammasome activation in human placental macrophages

L. Rogers, C. H. Serezani, A. Eastman, A. Hasty, L. Englund-Ogge, B. Jacobsson, K. Vickers, D. M. Aronoff

This study shows that palmitate induces NLRP3 inflammasome activation and apoptosis in human placental macrophages, while glucose and insulin do not contribute to these effects.

bioRxiv · Oct 10, 2019Immunology