A. Garnham

Total testosterone is not associated with muscle mass, function or exercise adaptations in pre-menopausal females

This study finds that total testosterone is not linked to muscle mass or strength in pre-menopausal females, but bioavailable testosterone and nuclear-localized androgen receptor are associated with muscle hypertrophy.

A multi-organ map of the human immune system across age, sex and ethnicity

The paper creates a comprehensive immune system map across age, sex, and ethnicity using single-cell RNA sequencing data, revealing immune ageing patterns and ethnic diversity in immune checkpoints.

Deletion of the transcriptional regulator TFAP4 accelerates c-MYC-driven lymphomagenesis

This study shows that deleting TFAP4 in E-MYC transgenic mice accelerates lymphoma development by blocking B cell differentiation.

MLKL deficiency protects against low-grade, sterile inflammation in aged mice

This study shows that MLKL deficiency reduces age-related sterile inflammation in mice by preserving lymphocyte levels and reducing inflammatory infiltrates in tissues.

Interpretation of exercise-induced changes in human skeletal muscle mRNA expression depends on the timing of the post-exercise biopsies

This study shows that the timing of post-exercise muscle biopsies significantly affects the observed mRNA expression changes, emphasizing the need for comprehensive time-course analysis in exercise research.

Exercise mitigates sleep-loss-induced changes in glucose tolerance, mitochondrial function, sarcoplasmic protein synthesis, and circadian rhythms.

This study shows that high-intensity interval exercise mitigates sleep loss-induced impairments in glucose tolerance, mitochondrial function, sarcoplasmic protein synthesis, and circadian rhythms.

The effect of acute sleep deprivation on skeletal muscle protein synthesis and the hormonal environment

This study shows that acute sleep deprivation reduces skeletal muscle protein synthesis and alters hormonal profiles, creating a pro-catabolic environment.

Vasoactive intestinal peptide confers anticipatory mucosal immunity by regulating ILC3 activity

This study shows that vasoactive intestinal peptide (VIP) regulates ILC3 activity to enhance IL-22 production and confer gut protection through the VIP-VIPR2 pathway.

Toxoplasma gondii bradyzoites induce transcriptional changes to host cells and prevent IFNγ-mediated cell death

This study shows that Toxoplasma gondii bradyzoites alter host cell transcription and prevent IFNγ-mediated cell death through protein export.