Molecular pathways and cellular subsets associated with adverse clinical outcomes in overlapping immune-related myocarditis and myositis
B. A. Siddiqui, N. L. Palaskas, S. Basu, Y. Dai, Z. He, S. S. Yadav, J. Allison, R. Sheth, S. Tummala, L. M. Buja, M. Bhattacharjee, C. A. Iliescu, A. Rawther-Karedath, A. Deswal, L. Wang, , S. K. Subudhi
The paper uses single-cell RNA sequencing to identify molecular pathways and immune subsets in immune-related myocarditis and myositis, finding clonally expanded CD8+ T cells and specific myeloid cell populations associated with adverse outcomes.
bioRxiv · Sep 15, 2023Immunology