Author

M. Doerflinger

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Cell Biology· 1 Immunology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:host-pathogen & immune response· 3 Organism:human· 2 Organism:mouse· 2 Assay:proteomics· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:development & morphogenesis· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

G. Atkin-Smith· 2 shared G. Ebert· 2 shared A. E. Au· 1 shared A. H. Buultjens· 1 shared A. Jacobsen· 1 shared A. K. Coussens· 1 shared A. L. Samson· 1 shared A. P. Ng· 1 shared

Activity by Year

2020-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 17 mutual co-author links

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2 shared papersCell Biology

G. Atkin-Smith

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Author profile →

4 papers

Recent·Most cited

Mycobacterium ulcerans challenge strain selection for a Buruli ulcer controlled human infection model

S. Muhi, A. H. Buultjens, J. L. Porter, J. L. Marshall, M. Doerflinger, S. J. Pidot, D. O'Brien, P. D. R. Johnson, C. Lavender, M. Globan, J. McCarthy, J. Osowicki, T. P. Stinear

This paper identifies M. ulcerans JKD8049 as a suitable human challenge strain for Buruli ulcer research due to its stability, antibiotic susceptibility, and ability to produce mycolactone.

bioRxiv · Feb 8, 2024 · PreprintMicrobiology

Voltage-gated T-type calcium channel blockers reduce apoptotic body-mediated SARS-CoV-2 cell-to-cell spread and subsequent cytokine storm

T. K. Phan, D. Sheerin, B. Shi, M. Dayton, L. Mackiewicz, D. C. Ozkocak, G. Atkin-Smith, N. Peton, O. Audi, R. Tixeira, G. Ashdown, K. C. Davidson, M. Doerflinger, A. K. Coussens, I. K. H. Poon

This study shows that T-type calcium channel blockers reduce SARS-CoV-2 spread via apoptotic bodies and limit cytokine storms in macrophages.

bioRxiv · Nov 3, 2023 · PreprintCell Biology

A common human MLKL polymorphism confers resistance to negative regulation by phosphorylation

S. E. Garnish, K. R. Martin, M. Kauppi, V. Jackson, R. Ambrose, V. V. Eng, S. Chiou, Y. Meng, D. Frank, E. C. Tovey Crutchfield, K. M. Patel, A. Jacobsen, G. Atkin-Smith, L. Di Rago, M. Doerflinger, , J. Hildebrand

The paper shows that a common MLKL polymorphism, S132P, enhances necroptotic activity in human cells and impairs recovery from infection in mice.

bioRxiv · Sep 8, 2022 · PreprintImmunology

Mechanism and inhibition of SARS-CoV-2 PLpro

T. Klemm, G. Ebert, D. J. Calleja, C. C. Allison, L. W. Richardson, J. P. Bernardini, B. G. C. Lu, N. W. Kuchel, C. Grohmann, Y. Shibata, Z. Y. Gan, J. P. Cooney, M. Doerflinger, A. E. Au, T. R. Blackmore, , D. Komander

This study investigates SARS-CoV-2 PLpro's mechanism and identifies non-covalent inhibitors with antiviral activity.

bioRxiv · Jun 18, 2020Biochemistry