Author

S. Chiou

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 2 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:mouse· 3 Research Focus:development & morphogenesis· 2 Research Focus:host-pathogen & immune response· 2 Organism:human· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Approach:genetic perturbation / CRISPR· 1

Frequent Co-Authors

A. L. Samson· 3 shared C. Hall· 3 shared J. M. Murphy· 3 shared A. Hempel· 2 shared A. Jacobsen· 2 shared I. Wicks· 2 shared J. Day· 2 shared J. Hildebrand· 2 shared

Activity by Year

2022-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersImmunology

A. L. Samson

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Author profile →

3 papers

Recent·Most cited

An immunohistochemical atlas of necroptotic pathway expression

S. Chiou, A. Al-Ani, Y. Pan, K. Patel, I. Kong, L. Whitehead, A. Light, S. Young, M. Barrios, C. Sargeant, P. Rajasekhar, L. Zhu, A. Hempel, A. Lin, J. Rickard, , A. L. Samson

The paper develops automated immunohistochemistry protocols to detect necroptotic pathway proteins in mouse and human tissues, revealing heterogeneity and disease-related changes in expression.

bioRxiv · Oct 31, 2023Cell Biology

MLKL deficiency protects against low-grade, sterile inflammation in aged mice

E. C. Tovey, S. E. Garnish, J. Day, H. Anderton, S. Chiou, A. Hempel, C. Hall, K. Patel, P. Gangatirkar, C. S. N. Li Wai Suen, A. Garnham, A. J. Kueh, U. Nachbur, A. L. Samson, J. M. Murphy, J. M. Hildebrand

This study shows that MLKL deficiency reduces age-related sterile inflammation in mice by preserving lymphocyte levels and reducing inflammatory infiltrates in tissues.

bioRxiv · Oct 17, 2022 · PreprintImmunology

A common human MLKL polymorphism confers resistance to negative regulation by phosphorylation

S. E. Garnish, K. R. Martin, M. Kauppi, V. Jackson, R. Ambrose, V. V. Eng, S. Chiou, Y. Meng, D. Frank, E. C. Tovey Crutchfield, K. M. Patel, A. Jacobsen, G. Atkin-Smith, L. Di Rago, M. Doerflinger, , J. Hildebrand

The paper shows that a common MLKL polymorphism, S132P, enhances necroptotic activity in human cells and impairs recovery from infection in mice.

bioRxiv · Sep 8, 2022 · PreprintImmunology