Author

S. Higginbottom

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 4 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Research Focus:host-pathogen & immune response· 5 Organism:mouse· 5 Assay:metagenomics· 4 Assay:proteomics· 3 Research Focus:cell type annotation· 2 Organism:C. elegans· 1 Research Focus:clustering· 1

Frequent Co-Authors

M. Wang· 3 shared A. Weakley· 2 shared A. Zhao· 2 shared J. L. Sonnenburg· 2 shared J. Sonnenburg· 2 shared K. Atabakhsh· 2 shared K. Nagashima· 2 shared M. A. Fischbach· 2 shared

Activity by Year

2018-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

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3 shared papersMicrobiology

M. Wang

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Fermented foods restructure gut microbiota and promote immune regulation via microbial metabolites

S. P. Spencer, E. G. Lemus Silva, E. Caffrey, R. N. Culver, R. H. Gellman, M. Wang, H. Wastyk, S. Higginbottom, J. L. Sonnenburg

This study shows fermented foods reshape gut microbiota and enhance immune regulation through microbial metabolites, independent of live microbes.

bioRxiv · May 11, 2022 · PreprintMicrobiology

Mapping the T cell repertoire to a complex gut bacterial community

K. Nagashima, A. Zhao, K. Atabakhsh, A. Weakley, S. Jain, X. Meng, A. Cheng, M. Wang, S. Higginbottom, A. Dimas, P. Murugkar, M. A. Fischbach

The paper maps T cell responses to a complex gut bacterial community and identifies a conserved antigen recognized by multiple TCRs.

bioRxiv · May 4, 2022Immunology

In vivo augmentation of a complex gut bacterial community

A. G. Cheng, P.-Y. Ho, S. Jain, X. Meng, M. Wang, B. Yu, M. Iakiviak, A. R. Brumbaugh, K. Nagashima, A. Zhao, A. Patil, K. Atabakhsh, A. Weakley, J. Yan, S. Higginbottom, , M. A. Fischbach

The paper improves a synthetic gut microbiota community by adding strains that persist after fecal challenge and removing those that do not, resulting in a more stable model of the human gut microbiome.

bioRxiv · Jun 15, 2021Microbiology

Mucin-derived O-glycans supplemented to diet mitigate diverse microbiota perturbations

K. M. Pruss, A. Marcobal, A. Southwick, D. Dahan, S. Smits, J. Ferreyra, S. Higginbottom, E. Sonnenburg, P. Kashyap, B. Choudhury, L. Bode, J. Sonnenburg

The paper shows that mucin-derived O-glycans can restore microbiota balance and improve host health by promoting beneficial microbes and suppressing pathogens.

The ISME Journal · Oct 21, 2020Peer-reviewedMicrobiology

Depletion of microbiome-derived molecules in the host using Clostridium genetics

C.-J. Guo, B. Allen, K. Hiam, D. Dodd, W. van Treuren, S. Higginbottom, C. Fischer, J. Sonnenburg, M. Spitzer, M. Fischbach

This study develops a genetic method to disable Clostridium species and investigates the impact of microbiome-derived molecules on host IgA modulation.

bioRxiv · Aug 27, 2018Microbiology