Human FcγRIIIa activation on splenic macrophages drives the in vivo pathogenesis of dengue disease
R. Yamin, K. S. Kao, M. R. MacDonald…·S. Bournazos
This study shows that anti-DENV IgG antibodies drive dengue pathogenesis via FcγRIIIa on splenic macrophages, leading to inflammation and mortality.