P. Seth

The atypical cadherin FAT1 is a novel regulator of STAT1, driving its pro-tumorigenic effect via the STAT1/PDCD4 axis in glioblastoma

This study identifies STAT1 as a downstream mediator of FAT1, showing it suppresses PDCD4 to drive pro-tumorigenic effects in glioblastoma.

Sulfide oxidation promotes hypoxic angiogenesis and neovascularization

This study shows that sulfide oxidation via SQOR promotes hypoxic angiogenesis and neovascularization by reprogramming metabolic pathways in endothelial cells.

Copper dependent ERK1/2 phosphorylation is essential for the viability of neurons and not glia

This study shows that copper-dependent ERK1/2 phosphorylation is essential for neuronal viability but not glial cells during differentiation.

iRGD-liposomes enhance tumor delivery and therapeutic efficacy of antisense oligonucleotide drugs against primary prostate cancer and bone metastasis

This paper demonstrates that iRGD-liposomes enhance the delivery and efficacy of AR-ASO in treating prostate cancer and bone metastasis without increasing toxicity.

Vortex chip incorporating an orthogonal turn for size-based isolation of circulating cells

The paper introduces a vortex chip with an orthogonal turn to isolate circulating cells based on size at lower flow velocities, demonstrating selective trapping of breast cancer cells in blood.

Origin of a novel CYP20A1 transcript isoform through multiple Alu exaptations creates a potential miRNA sponge

The paper identifies a novel CYP20A1 transcript isoform generated by Alu exaptation that functions as a miRNA sponge in human neurons.

Identification and classification of hubs in miRNA target gene networks in human neural stem/progenitor cells following Japanese encephalitis virus infection

The paper identifies and classifies hub genes in miRNA target networks of human neural stem/progenitor cells infected with Japanese encephalitis virus.