Author

R. Cook

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 6 Bioengineering· 1 Ecology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Assay:metagenomics· 3 Approach:statistical model· 3 Assay:bulk RNA-seq· 2 Assay:long-read sequencing· 2 Approach:benchmark study· 1 Research Focus:benchmarking· 1 Research Focus:cell type annotation· 1

Frequent Co-Authors

A. D. Millard· 4 shared D. J. Stekel· 4 shared B. Rihtman· 3 shared J. Hobman· 3 shared M. Jones· 3 shared A. Millard· 2 shared M. A. Jones· 2 shared N. Brown· 2 shared

Activity by Year

2020-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 38 mutual co-author links

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4 shared papersMicrobiology

A. D. Millard

Mutual co-authors in cluster

Author profile →

8 papers

Recent·Most cited

Decoding Huge Phage Diversity: A Taxonomic Classification of Lak Megaphages

R. Cook, M. A. Crisci, H. V. Pye, A. Telatin, E. M. Adriaenssens, J. M. Santini

The paper classifies Lak megaphages into a new viral order, Grandevirales, based on protein and nucleotide analyses, revealing their unique genetic code and evolutionary relationships.

bioRxiv · Feb 1, 2024 · PreprintMicrobiology

Structural Optimization of siRNA Conjugates for Albumin Binding Achieves Effective MCL1-Targeted Cancer Therapy

E. Hoogenboezem, S. S. Patel, A. Cavnar, J. Lo, L. Babb, N. Francini, P. Patil, J. Colazo, D. L. Michell, V. Sanchez, J. McCune, J. Ma, C. DeJulius, L. Lee, J. Rosch, , C. Duvall

This paper optimizes siRNA conjugates for albumin binding to enhance tumor delivery and efficacy in cancer therapy, achieving 80% MCL1 silencing and improved survival in breast cancer models.

bioRxiv · Feb 14, 2023 · PreprintBioengineering

The long and short of it: Benchmarking viromics using Illumina, Nanopore and PacBio sequencing technologies

R. Cook, N. Brown, B. Rihtman, S. Michniewski, T. Redgwell, D. J. Stekel, J. Hobman, Y. Chen, A. Nelson, D. Scanlan, M. A. Jones, D. Smith, A. D. Millard

This paper benchmarks viromics using Illumina, Nanopore, and PacBio sequencing technologies to assess their impact on viral community reconstruction and error rates.

bioRxiv · Feb 12, 2023Microbiology

Ecological and evolutionary patterns of virus-host interactions throughout a grassland soil depth profile

G. Muscatt, R. Cook, A. Millard, G. D. Bending, E. Jameson

The paper investigates virus-host interactions in grassland soil across depth profiles, revealing ecological and evolutionary patterns and evidence of carbon remineralization by soil viruses.

bioRxiv · Dec 9, 2022 · PreprintEcology

Antimicrobial resistance in dairy slurry tanks: a critical point for measurement and control

M. Baker, A. D. Williams, S. P. T. Hooton, R. Helliwell, E. King, T. Dodsworth, R. M. Baena-Nogueras, A. Warry, C. A. Ortori, H. Todman, C. J. Gray-Hammerton, A. C. W. Pritchard, E. Iles, R. Cook, R. D. Emes, , D. J. Stekel

This study identifies dairy slurry tanks as critical for antimicrobial resistance (AMR) prevalence and control, showing that 60 days of storage can reduce ARB spread by >99%.

bioRxiv · Feb 22, 2022Microbiology

Identification of a new family of "megaphages" that are abundant in the marine environment

S. Michniewski, B. Rihtman, R. Cook, M. Jones, W. Wilson, D. D. Scanlan, A. Millard

The paper identifies a new family of marine megaphages with large genomes and novel metabolic genes.

bioRxiv · Jul 26, 2021 · PreprintMicrobiology

INfrastructure for a PHAge REference Database: Identification of large-scale biases in the current collection of phage genomes

R. Cook, N. Brown, T. Redgwell, B. Rihtman, M. Barnes, D. J. Stekel, M. Clokie, J. Hobman, M. Jones, A. D. Millard

The paper develops a tool to extract phage genomes and identifies biases in their representation, such as overrepresentation of lytic phages and limited host diversity.

bioRxiv · May 1, 2021Microbiology

Hybrid assembly of an agricultural slurry virome reveals a diverse and stable community with the potential to alter the metabolism and virulence of veterinary pathogens

R. Cook, S. Hooton, U. Trivedi, L. King, C. Dodd, J. Hobman, D. J. Stekel, M. Jones, A. D. Millard

The paper analyzes the virome of agricultural slurry using hybrid sequencing, revealing a diverse and stable community with potential to influence bacterial metabolism and virulence.

bioRxiv · Oct 8, 2020Microbiology