C.-T. Wu

Dietary protein restriction diminishes sucrose reward and reduces sucrose-evoked mesolimbic dopamine signaling

This study shows that dietary protein restriction reduces sucrose consumption and mesolimbic dopamine signaling in mice.

Filopodial Mechanotransduction is regulated by Angiotensin-Converting Enzyme 2 (ACE2) and by SARS-CoV-2 spike protein

The paper investigates how SARS-CoV-2 spike protein activates calcium and actin dynamics to enable filopodial extension and virus binding through ACE2.

Cryosectioning-enhanced super-resolution microscopy for single-protein imaging across cells and tissues

The paper introduces tkPAINT, a method combining TIRF microscopy and Tokuyasu cryosectioning to enhance DNA-PAINT for single-protein imaging and molecular counting with 3 nm precision across cells and tissues.

The macronutrient content of a meal modulates subsequent 'dessert' intake, via Fibroblast Growth Factor 21 (FGF21)

The study shows that a low protein pre-load increases subsequent high protein intake in mice, but does not reduce sweet dessert consumption, suggesting FGF21's role in protein intake rather than sweet food suppression.

Iterative transcription factor screening enables rapid generation of microglia-like cells from human iPSC

This study uses iterative transcription factor screening to generate microglia-like cells from human iPSCs, identifying a combination of TFs that efficiently differentiate iPSCs into microglia-like cells within 4 days.

Ethacridine inhibits SARS-CoV-2 by inactivating viral particles in cellular models

This study identifies ethacridine, an FDA-approved antiseptic, as a potent inhibitor of SARS-CoV-2 by inactivating viral particles in cellular models.

Discovery of ciliary G protein-coupled receptors regulating pancreatic islet insulin and glucagon secretion

The paper identifies ciliary GPCRs in pancreatic islet cells that regulate insulin and glucagon secretion, with FFAR4 and PTGER4 as key targets for diabetes therapy.