Author

S. Kotschi

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Physiology· 2 Biochemistry· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:human· 3 Organism:mouse· 3 Assay:proteomics· 3 Research Focus:cancer & tumor microenvironment· 2 Research Focus:cell signaling & trafficking· 2 Research Focus:cell type annotation· 2 Approach:genetic perturbation / CRISPR· 2

Frequent Co-Authors

A. Bartelt· 3 shared C. Jethwa· 2 shared D. T. Egu· 2 shared J. Waschke· 2 shared N. Willemsen· 2 shared S. Herzig· 2 shared S. Khani· 2 shared A. Ghosh· 1 shared

Activity by Year

2021-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 32 mutual co-author links

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3 shared papersPhysiology

A. Bartelt

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Control of cholesterol-induced adipocyte inflammation by the Nfe2l1-Atf3 pathway

C. Jethwa, A. Hoffmann, S. Kotschi, J. Caesar, M. Kern, A. Worthmann, C. Schlein, S. Khani, B. A. Arus, O. T. Bruns, A. Ghosh, C. Wolfrum, Y. Döring, S. Herzig, C. Weber, , A. Bartelt

This study identifies the Nfe2l1-Atf3 pathway as a regulator of cholesterol-induced adipocyte inflammation and insulin resistance in both human and mouse models.

bioRxiv · Jul 22, 2024 · PreprintPhysiology

The myocyte Nfe2l1-ubiquitin-proteasome system controls muscle fiber type and obesity-induced insulin resistance

I. L. Lemmer, D. T. Haas, N. Willemsen, S. Kotschi, I. Toksoez, E. Gjika, S. Khani, M. Rohm, N. Diercksen, P. B. H. Nguyen, M. P. Menden, D. T. Egu, J. Waschke, S. Larsen, T. Ma, , A. Mena Gomez

This study shows that Nfe2l1 regulates skeletal muscle proteostasis and function, with its loss causing muscle fiber type switching and insulin resistance in high-fat diet conditions.

bioRxiv · Apr 20, 2023 · PreprintPhysiology

Apremilast prevents blistering in human epidermis by stabilization of keratinocyte adhesion in pemphigus.

A. M. Sigmund, M. Winkler, S. Engelmayer, D. T. Egu, D. Kugelmann, M. Y. Radeva, F. C. Bayerbach, S. Kotschi, S. Yeruva, E. Schmidt, A. S. Yazdi, K. Ghoreschi, F. Vielmuth, J. Waschke

This study shows apremilast stabilizes keratinocyte adhesion in pemphigus by phosphorylating plakoglobin at serine 665, preventing blistering without affecting desmoglein depletion or binding.

bioRxiv · Feb 7, 2022Cell Biology

NFE2L1-mediated proteasome function protects from ferroptosis

S. Kotschi, A. Jung, N. Willemsen, A. Ofoghi, B. Proneth, M. Conrad, A. Bartelt

This study identifies NFE2L1 as a regulator of proteasome function that protects cells from ferroptosis, with implications for cancer and neurodegenerative diseases.

bioRxiv · Dec 12, 2021Biochemistry