T. Carell

Generation of densely labeled oligonucleotides for the detection of small genomic elements

This paper introduces a method to generate densely labeled oligonucleotides for detecting small genomic elements using FISH in single cells.

Human TRMT2A methylates tRNA and contributes to translation fidelity

This study identifies TRMT2A as a tRNA methyltransferase that contributes to translation fidelity by modifying tRNA with m5U at position 54.

Epigenetic anti-cancer treatment with a stabilized carbocyclic Decitabine analogue

This paper evaluates a stabilized carbocyclic Decitabine analogue, showing it effectively inhibits DNMT1 and induces more DNA damage in cancer cells with less toxicity.

1H NMR chemical exchange techniques reveal local and global effects of oxidized cytosine derivatives

This study uses NMR to show that 5caC destabilizes DNA globally and increases base-pair mobility locally, with effects dependent on pH and temperature.

Synthesis and Structure Elucidation of the Human tRNA Nucleoside Mannosyl-Queuosine

The paper reports the correct structure of mannosyl-queuosine (manQ) through total synthesis and LC-MS-co-injection, revealing a novel -allyl connectivity and differing glycosylase preferences.

Oxidative and non-oxidative active turnover of genomic methylcytosine in distinct pluripotent states

The paper quantifies DNA methylation turnover in mouse pluripotent cells, revealing active oxidation-dependent and -independent processes in formative and primed states.

DNA hydroxymethylation reveals transcription regulation networks and prognostic signatures in multiple myeloma

This study analyzes DNA hydroxymethylation in multiple myeloma to identify regulation networks and prognostic signatures associated with disease progression and survival.

Distinct and stage-specific contributions of TET1 and TET2 to stepwise cytosine oxidation in the transition from naive to primed pluripotency

The paper compares TET1 and TET2 contributions to cytosine oxidation during naive to primed pluripotency transition, finding distinct and differentiation-dependent roles in 5hmC and 5fC formation.