Author

W. C. Chen

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

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Cancer Biology· 4

Signature Assays, Organisms & Methods

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Organism:human· 4 Approach:statistical model· 4 Research Focus:differential expression· 3 Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 2 Research Focus:clustering· 2 Approach:deep learning· 2 Research Focus:drug response / drug discovery· 2

Frequent Co-Authors

D. R. Raleigh· 3 shared A. Choudhury· 2 shared A. Perry· 2 shared S. T. Magill· 2 shared A. Ashworth· 1 shared A. B. Heimberger· 1 shared A. Bhaduri· 1 shared A. G. X. Zeng· 1 shared

Activity by Year

2022-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 23 mutual co-author links

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3 shared papersCancer Biology

D. R. Raleigh

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Author profile →

4 papers

Recent·Most cited

Meningioma transcriptomic landscape demonstrates novel subtypes with regional associated biology and patient outcome.

H. N. Thirimanne, D. A. Bonnin, N. Nuechterlein, S. Arora, M. Jensen, C. A. Parada, C. Qiu, F. Szulzewsky, C. W. English, W. C. Chen, P. Sievers, F. Nassiri, J. Z. Wang, T. J. Klisch, K. D. Aldape, , E. C. Holland

This study combines bulk RNA-Seq datasets to create a transcriptomic landscape of meningiomas, identifies subtypes with distinct biology and prognosis, and provides an interactive tool for outcome prediction.

bioRxiv · Feb 23, 2024Cancer Biology

Epigenetic reprogramming shapes the cellular landscape of schwannoma

S. J. Liu, T. Casey-Clyde, N. W. Cho, J. Swinderman, M. Pekmezci, M. C. Dougherty, K. Foster, W. C. Chen, J. E. Villanueva-Meyer, D. L. Swaney, H. N. Vasudevan, A. Choudhury, J. D. Breshears, U. E. Lang, C. D. Eaton, , D. R. Raleigh

This study identifies two molecular groups in schwannomas driven by epigenetic reprogramming and shows ionizing radiation can reprogram neural crest to immune-enriched schwannomas.

Nature Communications · Jan 12, 2024Peer-reviewedCancer Biology

NOTCH3 drives meningioma tumorigenesis and resistance to radiotherapy

A. Choudhury, M. A. Cady, C.-H. G. Lucas, H. Najem, J. J. Phillips, B. Palikuqi, N. Zakimi, T. Joseph, J. O. Birreuta, W. C. Chen, N. A. O. Bush, S. L. Hervey-Jumper, O. D. Klein, C. M. Toedebusch, C. M. Horbinski, , D. R. Raleigh

This study identifies NOTCH3 as a driver of meningioma tumorigenesis and radiotherapy resistance, showing its role in tumor growth and survival in preclinical models.

bioRxiv · Jul 10, 2023 · PreprintCancer Biology

A cellular hierarchy framework for understanding heterogeneity and predicting drug response in AML

A. G. X. Zeng, S. Bansal, L. Jin, A. Mitchell, W. C. Chen, H. A. Abbas, M. Chan-Seng-Yue, V. Voisin, P. van Galen, A. Tierens, M. Cheok, C. Preudhomme, H. Dombret, N. Daver, P. A. Futreal, , J. E. Dick

This study identifies a cellular hierarchy framework in AML that links disease heterogeneity with drug response and develops a 7-gene biomarker predictive of drug sensitivity.

bioRxiv · Jan 25, 2022Cancer Biology