Author

X. Fei

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 3 Biochemistry· 2 Cell Biology· 2 Plant Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 8 Assay:cryo-EM· 5 Organism:E. coli· 4 Research Focus:cell type annotation· 3 Research Focus:protein folding & dynamics· 3 Research Focus:differential expression· 2 Research Focus:gene regulatory network inference· 2 Organism:plant (other)· 2

Frequent Co-Authors

R. T. Sauer· 5 shared T. A. Baker· 5 shared T. A. Bell· 3 shared A. Wei· 2 shared H. Hu· 2 shared J. H. Davis· 2 shared J. Li· 2 shared Y. LIu· 2 shared

Activity by Year

2019-2022 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

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5 shared papersBiophysics

R. T. Sauer

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8 papers

Recent·Most cited

The SspB adaptor drives structural changes in the AAA+ ClpXP protease during ssrA-tagged substrate delivery

A. Garbhanpour, X. Fei, T. A. Baker, J. H. Davis, R. T. Sauer

This paper presents a cryo-EM structure of the SspB adaptor bound to ClpXP and a tagged substrate, revealing structural changes in ClpX and its interaction with ClpP during substrate delivery.

bioRxiv · Nov 6, 2022Biochemistry

A closed translocation channel in the substrate-free AAA+ ClpXP protease diminishes rogue degradation

A. Ghanbarpour, S. E. Cohen, X. Fei, T. A. Bell, T. A. Baker, J. H. Davis, R. T. Sauer

The paper presents cryo-EM structures of E. coli ClpXP, showing that a closed axial channel in ClpX enhances degradation specificity by preventing non-specific substrate entry.

bioRxiv · Aug 27, 2022Biochemistry

HSP90.6 is involved in grain filling via carbon and nitrogen metabolism in maize.

J. Xu, Z. Yang, X. Fei, M. Zhang, Y. Cui, X. zhang, K. Tan, L. E, H. Zhao, J. Lai, Q. Zhao, W. Song

HSP90.6 regulates maize grain filling by affecting 26S proteasome-mediated nitrogen recycling and GF14-6-mediated carbon metabolism.

bioRxiv · Apr 27, 2022 · PreprintPlant Biology

AAA+ protease-adaptor structures reveal altered conformations and ring specialization

S. Kim, X. Fei, R. T. Sauer, T. A. Baker

The paper presents cryo-EM structures of ClpAPS complexes, revealing how pore loops interact with the ClpS NTE and showing asymmetry in engagement by the D1 and D2 rings.

bioRxiv · Feb 4, 2022Biophysics

Structural basis of ClpXP recognition and unfolding of ssrA-tagged substrates

X. Fei, T. A. Bell, S. R. Barkow, T. A. Baker, R. T. Sauer

The paper presents cryo-EM structures of ClpXP bound to the ssrA degron, revealing how it recognizes and unfolds ssrA-tagged substrates through a multistep process.

eLife · Oct 22, 2020Peer-reviewedBiophysics

Structures of the ATP-fueled ClpXP proteolytic machine bound to protein substrate

X. Fei, T. A. Bell, S. Jenni, B. M. Stinson, T. A. Baker, S. C. Harrison, R. T. Sauer

This study presents cryo-EM structures of the E. coli ClpXP protease complex, revealing how ClpX interacts with ClpP and substrates, and proposes models for its ATP-dependent proteolytic mechanism.

bioRxiv · Oct 31, 2019Biophysics

Identification of microRNA-target interactions for antioxidant defense response under drought stress by high-throughput sequencing in Zanthoxylum bungeanum Maxim.

X. Fei, H. Hu, J. Li, Y. LIu, A. Wei

bioRxiv · May 16, 2019 · PreprintCell Biology

Drought Affects the Antioxidant System and Stomatal Aperture in Zanthoxylum bungeanum Maxim.

X. Fei, H. Hu, J. Li, Y. Liu, A. Wei

This study examines how drought affects the antioxidant system and stomatal aperture in Zanthoxylum bungeanum by analyzing enzyme activities, gene expression, and stomatal changes under drought conditions.

bioRxiv · Mar 14, 2019 · PreprintCell Biology