Author

Y. Ali

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Cell Biology· 2 Immunology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:mouse· 4 Approach:statistical model· 4 Assay:bulk RNA-seq· 3 Research Focus:cell type annotation· 3 Research Focus:differential expression· 3 Organism:human· 3 Assay:scRNA-seq· 2

Frequent Co-Authors

F. Yong· 2 shared G. A. Rutter· 2 shared L. Delgadillo-Silva· 2 shared R. Sladek· 2 shared A. Marta· 1 shared A. Martinez-sanchez· 1 shared A. Montoya· 1 shared A. Osakwe· 1 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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Curved chords = mutual co-authorship

2 shared papersCell Biology

F. Yong

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Differential CpG methylation at Nnat in the early establishment of beta cell heterogeneity

V. Yu, F. Yong, A. Marta, S. Khadayate, A. Osakwe, S. Bhattacharya, S. S. Varghese, P. Chabosseau, S. M. Tabibi, K. Chen, E. Georgiadou, N. Parveen, M. Suleiman, Z. Stamoulis, L. Marselli, , S. J. Millership

This study identifies differential CpG methylation at the Nnat gene as a mechanism establishing beta cell heterogeneity during development and its potential role in diabetes.

bioRxiv · Feb 4, 2023Cell Biology

Angiopoietin-like 4 shapes the intrahepatic T-cell landscape via eIF2α signalingduring steatohepatitis in diet-induced NAFLD.

Z. S. LOW, D. CHUA, H. S. CHENG, R. TEE, W. R. TAN, C. BALL, N. B. E. SAHIB, S. S. NG, J. QU, Y. LIU, H. HONG, C. CAI, N. C. L. RAO, A. WEE, M. D. MUTHIAH, , W. WAHLI

The paper identifies Angptl4's role in shaping intrahepatic T-cell activation via eIF2α signaling during fibrosis in diet-induced NAFLD.

bioRxiv · Jan 10, 2023 · PreprintImmunology

Purine and carbohydrate availability drive Enterococcus faecalis fitness during wound infection

C. A. Z. Tan, K. K. L. Chong, D. Y. X. Yeong, C. H. M. Ng, M. H. Ismail, V. S. Y. Tay, Y. Ali, K. A. Kline

This study identifies purine biosynthesis and the MptABCD phosphotransferase system as critical for E. faecalis replication and persistence during wound infection, driven by microenvironmental changes.

bioRxiv · Oct 17, 2022 · PreprintMicrobiology

Molecular phenotyping of single pancreatic islet leader beta cells by Flash-Seq

P. Chasbosseau, F. Yong, L. Delgadillo-Silva, E. Young Lee, S. Li, N. Gandhi, J. Wastin, L. Lopez-Noriega, I. Leclerc, Y. Ali, J. HUGHES, R. Sladek, A. Martinez-sanchez, G. A. Rutter

The paper identifies leader beta cells in pancreatic islets using Flash-Seq and finds they have a distinct transcriptome and localization compared to follower cells.

bioRxiv · Aug 26, 2022Cell Biology

Destabilization of β-cell FIT2 by saturated fatty acids contribute to ER stress and diabetes

X. Zheng, Q. W. C. Ho, M. Chua, O. Stelmashenko, S. Muralidharan, F. T. Torta, E. G. Y. Chew, M. M. Lian, J. N. Foo, M. R. Wenk, D. L. Silver, P.-O. Berggren, Y. Ali

This study shows that saturated fatty acids reduce β-cell lipid droplets by destabilizing FIT2, leading to ER stress and diabetes, while FIT2 overexpression protects against these effects.

bioRxiv · Feb 28, 2021 · PreprintBiochemistry

Uncovering an allosteric mode of action for a selective inhibitor of human Bloom syndrome protein

X. Chen, Y. Ali, C. E. L. Fisher, R. Arribas-Bosacoma, M. B. Rajasekaran, G. Williams, S. Walker, J. R. Booth, J. J. R. Hudson, S. M. Roe, L. H. Pearl, S. E. Ward, F. M. G. Pearl, A. W. Oliver

The paper identifies an allosteric inhibitor of BLM's ATPase-coupled DNA helicase activity and characterizes its mechanism through crystallographic analysis.

bioRxiv · Nov 30, 2020Biochemistry