Y.-J. Lu

Interdependence of plasma membrane nanoscale dynamics of a kinase and its cognate substrate underlies Arabidopsis response to viral infection

This study shows that CPK3 and its substrate REM1.2 interact dynamically at the plasma membrane, influencing viral propagation in Arabidopsis.

R-loop editing by DNA cytosine deaminase APOBEC3B determines the activity of estrogen receptor enhancers

This study shows APOBEC3B edits R-loops at ER enhancers, leading to DSBs that contribute to genomic instability in breast cancer.

Keratinocyte-tethering modification for biologics enables location-precise treatment in mouse vitiligo

This paper develops a bispecific antibody tethered to keratinocytes to locally block IFNγ in vitiligo, showing improved skin retention and reduced systemic effects.

Overexpression of NDR1 Leads to Pathogen Resistance at Elevated Temperatures

The paper shows NDR1 overexpression enhances pathogen resistance at elevated temperatures by maintaining immune signaling during ETI.

NDR1 and the Arabidopsis Plasma Membrane ATPase AHA5 are Required for Processes that Converge on Drought Tolerance and Immunity

This study shows NDR1 is required for drought tolerance and immunity by regulating H+-ATPase activity and stomatal dynamics in Arabidopsis.

CD4 T cell help prevents CD8 T cell exhaustion and promotes control of Mycobacterium tuberculosis infection

This study shows CD4 T cell help enhances CD8 T cell function and prevents exhaustion during M. tuberculosis infection, suggesting vaccines targeting both cell types may be more effective.

Correlation of p53 and DNA repair gene mutation patterns in human malignancies indicates different tumour suppression mechanisms of p53

The paper analyzes mutation patterns of p53 and DNA repair genes in human cancers to identify differences in p53's tumor suppression mechanisms across cancer types.