Author

Y.-X. Chen

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Pathology· 3 Immunology· 2 Microbiology· 2 Biochemistry· 1 Cancer Biology· 1 Ecology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 10 Assay:proteomics· 7 Research Focus:host-pathogen & immune response· 4 Organism:mouse· 4 Research Focus:cancer & tumor microenvironment· 2 Research Focus:cell type annotation· 2 Organism:human· 2 Organism:bacteria (other)· 1

Frequent Co-Authors

C. Shi· 3 shared E. R. O'Brien· 3 shared J. Deng· 3 shared B. Javid· 2 shared C. Diao· 2 shared J. Liu· 2 shared M. Rosin· 2 shared N. Maarouf· 2 shared

Activity by Year

2019-2022 · peak 6/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

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3 shared papersPathology

C. Shi

Mutual co-authors in cluster

Author profile →

10 papers

Recent·Most cited

PLK1 O-GlcNAcylation is essential for dividing mammalian cells and inhibits uterine carcinoma

S. Yan, B. Peng, S. Kan, G. Shao, Z. Xiahou, X. Tang, Y.-x. Chen, M.-Q. Dong, X. Liu, X. Xu, J. Li

This study identifies PLK1 O-GlcNAcylation as critical for cell division and shows its role in suppressing uterine carcinoma through biochemical and mouse model experiments.

bioRxiv · Aug 21, 2022 · PreprintCancer Biology

Mechanical morphotype switching as an adaptive response in mycobacteria

H. A. Eskandarian, Y.-X. Chen, C. Toniolo, J. M. Belardinelli, Z. Palcekova, P. D. Ashby, G. E. Fantner, M. Jackson, J. D. McKinney, B. Javid

The paper shows mycobacteria change their cell surface stiffness to survive macrophage stress, using mechanical morphotype switching as an adaptive strategy.

bioRxiv · Apr 6, 2022Microbiology

Effect of β-chitosan on the binding interaction between SARS-CoV-2 S-RBD and ACE2

G. Alitongbieke, X.-M. Li, Q.-C. Wu, Z.-C. Lin, J.-F. Huang, Y. Xue, J.-N. Liu, J.-M. Lin, T. Pan, Y.-X. Chen, Y. Su, G.-G. Zhang, B. Leng, S.-W. Liu, Y.-T. Pan

This paper shows β-chitosan blocks SARS-CoV-2 S-RBD binding to ACE2 and reduces inflammation, acting like an antibody and modulating ACE2 cleavage.

bioRxiv · Jul 31, 2020 · PreprintBiochemistry

Adopting STING agonist cyclic dinucleotides as a potential adjuvant for SARS-CoV-2 vaccine

J.-J. Wu, Y.-X. Chen, Y.-M. Li

This study shows that the STING agonist CDGSF enhances SARS-CoV-2 vaccine efficacy by boosting antibody and T cell responses compared to aluminium hydroxide.

bioRxiv · Jul 24, 2020 · PreprintImmunology

Heat Shock Protein 27 versus Estrogen Therapy for Post-Menopausal Atherosclerosis: Rethinking Mechanisms of Cholesterol Lowering

N. Maarouf, Y.-X. Chen, C. Shi, J. Deng, C. Diao, M. Rosin, V. Shrivastava, Z. Batulan, J. Liu, E. R. O'Brien

This study compares the effects of HSP25 vaccination and estrogen therapy on atherogenesis in post-menopausal mice, finding that both reduce plaque but through different mechanisms involving PCSK9 and LDLR.

bioRxiv · Jun 4, 2020Pathology

Heat Shock Protein 27 Immune Complex Altered Signaling and Transport (ICAST): Novel Mechanisms of Attenuating Inflammation

C. Shi, J. Deng, M. H. Chiu, Y.-X. Chen, E. R. O'Brien

The paper shows that HSP27 immune complexes reduce inflammation and cholesterol uptake by modulating TLR4 and scavenger receptors in macrophages.

bioRxiv · May 31, 2020Pathology

Heat Shock Protein 27 Immune Complex Upregulates LDLR Expression Thereby Reducing Plasma Cholesterol and Atherogenesis

Y.-X. Chen, C. Shi, J. Deng, C. Diao, N. Maarouf, M. Rosin, V. Shrivastava, A. Hu, S. Bharadwa, A. Adijiang, A. Ulke-Lemee, B. L. Gwilym, A. Hellmich, C. Malozzi, Z. Batulan, , E. R. O'Brien

The paper shows that HSP27 immune complexes increase LDLR expression, lowering plasma cholesterol and atherogenesis in ApoE-/- mice.

bioRxiv · May 21, 2020Pathology

Autophagy-associated Production of Antimicrobial Peptides hBD1 and LL37 Exhibits Anti-Bacillus Calmette-Guerin Effects in Lung Epithelial Cells.

R.-n. Wang, H.-l. Liu, Y.-x. Chen, Q. Wen, X.-y. Zhou, J.-l. Wang, J.-h. Yang, Y.-f. Li, Z.-y. Han, L. Ma

The paper shows that autophagy in lung epithelial cells enhances the production of antimicrobial peptides hBD1 and LL37, which kill intracellular Mycobacterium tuberculosis.

bioRxiv · Feb 21, 2020 · PreprintImmunology

Multifaceted diversity traits of crucial microbial groups in biological soil crusts promote soil multifunctionality

H. Li, Y.-X. Chen, G.-L. Yu, F. Rossi, D. Hua, R. De Philippis, X.-L. Cheng, W.-B. Wang, R.-H. Li

The paper evaluates multifaceted diversity traits of microbial groups in biological soil crusts to predict soil multifunctionality, finding that integrating multiple diversity components improves prediction over richness alone.

bioRxiv · Oct 8, 2019Ecology

Selective translation by alternative bacterial ribosomes

Y.-X. Chen, Z.-Y. Xu, X. Ge, S. Sanyal, Z. J. Lu, B. Javid

The paper shows that alternative ribosomes in Mycobacterium smegmatis have distinct translational features compared to canonical ribosomes, suggesting a regulatory role in gene translation.

bioRxiv · Aug 22, 2019Microbiology