Y.-M. Li

Di- and tri-methylation of histone H3K36 play distinct roles in DNA double-strand break repair

This study identifies distinct roles of H3K36 dimethylation and trimethylation in DNA double-strand break repair via NHEJ and HR in yeast and humans.

Phosphorylation and O-GlcNAcylation at the same alpha-synuclein site generate distinct fibril structures

This study shows that phosphorylation and O-GlcNAcylation at the same alpha-synuclein site generate distinct fibril structures with different neurotoxicity and propagation properties.

Adopting STING agonist cyclic dinucleotides as a potential adjuvant for SARS-CoV-2 vaccine

This study shows that the STING agonist CDGSF enhances SARS-CoV-2 vaccine efficacy by boosting antibody and T cell responses compared to aluminium hydroxide.

The framework of lncRNAs and genes at early pollen developmental stage in a PTGMS wheat line

The paper investigates the effect of low temperature on pollen fertility in a PTGMS wheat line using transcriptomic analysis and identifies cytoskeleton-related lncRNAs and their target genes involved in calcium signaling and vesicle trafficking.

Parkinson's disease-related phosphorylation at Tyr39 rearranges α-synuclein amyloid fibril structure revealed by cryo-EM

The paper determines the cryo-EM structure of phosphorylated α-synuclein fibrils at Tyr39, revealing structural changes linked to Parkinson's disease pathology.