RIPK3-dependent necroptosis is the primary cause of RIPK1-deficient-induced immunodeficiency.
X. Liu, X. Zhu, Z. Shu, L. Sun, H. Wang
This study identifies RIPK3-dependent necroptosis as the main cause of immunodeficiency in RIPK1-deficient rats and suggests necroptosis inhibition as a potential therapy.
bioRxiv · Feb 22, 2023 · PreprintImmunology