Cancer BiologyGastroenterologyPeer-reviewed
TET2 drives 5hmc marking of GATA6 and epigenetically defines pancreatic ductal adenocarcinoma transcriptional subtypes
M. Eyres, S. Lanfredini, A. Burns…·E. O'Neill
This study identifies TET2-driven 5hmc loss at GATA6 as a mechanism defining PDAC transcriptional subtypes and shows that TET2 stabilization with Metformin and Vitamin C reverses squamous-like tumor features.
DOI 10.1053/j.gastro.2021.04.044