human

This study examines changes in urinary extracellular vesicle miRNAs after high +Gz exposure, finding six miRNAs significantly altered with distinct temporal responses.

This paper establishes new disease models for SynGAP1-related disorder using patient-derived hiPSCs and humanized knock-in mice to study the effects of a SYNGAP1 nonsense mutation.

This study identifies RAC1P29S and MERTK as drivers of melanoma cell cannibalism of T cells through a 'grip and gulp' mechanism involving actin dynamics.

This study evaluates P2-based plasma enrichment for proteome coverage and biological consistency across preanalytical variables and cancer cohorts.

The paper examines oscillatory network directionality in the human medial temporal lobe during verbal working memory tasks, finding reversed directional patterns across encoding and retrieval phases.

The paper uses ChromBPNet to predict chromatin accessibility effects of noncoding variants across hematopoietic cell types, finding lineage-structured patterns and complementary insights with GWAS fine-mapping.

This study investigates how genetic diversity and multiplicity of infection in Plasmodium species affect Anopheles coluzzii infectivity in Cameroon, finding that higher diversity and mixed infections increase mosquito infectivity.

This study shows that aging reduces the ability to decrease reactive muscle responses during practice but maintains the ability to retrieve context-specific muscle patterns.

This study uses AlphaScreen profiling of extracellular vesicle markers to identify disease-specific signatures in ME/CFS, fibromyalgia, and long COVID, revealing distinct patterns of platelet, immune, and vascular pathway dysregulation.

This study uses EEG to track neural dynamics during physical exhaustion, finding that neural activity becomes more regular and predictable as exhaustion approaches, with participant-specific models accurately tracking proximity to exhaustion.

This study shows that RSA during slow-paced breathing correlates with generalized anxiety symptoms beyond resting RSA and interoceptive measures in young adults.

This study shows that HRV biofeedback changes neural activity but not subjective anxiety during a brief breathing exercise.

This study introduces a computational framework for designing antibodies that target multiple antigenic variants, including observed and forecasted ones, and demonstrates its effectiveness against cancer and viral antigens.

This paper develops algorithms for designing therapeutic oligonucleotides that account for genetic diversity by covering all paths in a pangenome graph within a bounded edit distance.

This study identifies how MAFB and MAF work together to shape human anti-inflammatory macrophage identity through IL-10 autocrine signaling and distinct functional roles.

The paper reassesses whether SGLT2 inhibitors directly activate PANK1 and finds they do not, challenging the proposed cardioprotective mechanism.

The paper analyzes age-related fibrosis in human choroid plexus and finds a negative correlation between fibrosis stages and lipid droplet presence in epithelial cells.

This study identifies ancestry-specific peripheral immune cell shifts in Alzheimer's disease across multi-ethnic cohorts using RNA-seq and deconvolution methods.

The paper shows that continuous ancestry profiles better capture genetic ancestry complexity than categorical labels, using genotyped data from 28,332 individuals.

This paper develops a luciferase reporter system to measure ester prodrug delivery and hydrolysis in mycobacteria, showing that permeation and intracellular unmasking depend on chain length and branching, respectively.

The paper identifies ciliated keratinocytes as a pro-inflammatory cell state in psoriasis and atopic dermatitis, showing their association with disease activity and response to treatment.

This study evaluates TACK compounds Pyr01 and Pyr02 for their ability to selectively eliminate HIV-1-infected macrophages, finding Pyr01 effectively targets infected cells while sparing uninfected ones.

This study maps the epigenomic circuits in pleural mesothelioma, identifies potential transcription factors and regulatory elements, and suggests their relevance to epigenetic editing strategies.

The study investigates whether selective auditory attention affects speech-like distortion product otoacoustic emissions (DPOAEs) in competing voices, finding no attentional modulation across stimulus types.

This study uses scRNA-seq to identify transcriptional signatures in CD4+ T cells from beryllium-exposed patients, revealing upregulated immune response genes and downregulated metabolic pathways.

The paper engineers a highly efficient PAMless genome editing system, eTasR, which significantly improves editing efficiency in mammalian cells and enables in vivo gene disruption.

The paper develops k-mer-based tools to measure Yq12 heterochromatin size from sequencing data without complete assemblies, revealing population-scale variation and transcription in testis.

This study compares antibiotic response phenotypes of Pseudomonas aeruginosa isolates under standard lab conditions and in an airway epithelial model, finding discordant results for some isolates.

ECMExplainer decodes cellular stress states and aging trajectories by analyzing matrisome gene-pair ratios across fibroblast transcriptomes.

The paper identifies an oxidative mutational signature in normal tissues of individuals carrying a single pathogenic MUTYH allele, suggesting a measurable mutational risk in healthy tissues.