Immune Cell Function and Interaction

This study maps human natural killer cell development in tonsil using single-cell analysis, showing spatial trajectories and tissue niches that support NK cell differentiation.

This study analyzes KIR diversity in HIV-infected children from Uganda and Botswana, finding differences in allele frequencies and associations with disease progression.

This study shows interferon-γ increases thrombospondin-4 expression in CTLs, promoting SMAP production and enhancing anti-tumor killing.

The paper identifies the HUSH complex as a regulator of EBV-transformed B cell sensitivity to NK cell surveillance by repressing the NKG2A ligand γ-protocadherin.

The paper investigates NK cell antigenic specificity by analyzing scRNA-Seq, single-cell cloning, and in silico modeling to show glycosylation's role in modulating KIR2DS4 interactions with peptide-MHCI complexes.

The paper investigates the CD48-CD244 axis in multiple myeloma, showing CD48 enhances NK-cell activation but contributes to NK exhaustion and poor prognosis.

This study shows that the anti-MHC-I antibody M1/42 enhances anti-tumor immunity by activating NK and adaptive immune cells, reducing metastasis in mouse models of cancer.

This study shows HLA-B51 activates human NK cells to produce IFN-γ, with KLRK1 as a key receptor, while IL-2 signals override HLA-B51 effects in some NK cell lines.

The paper shows CMV replication increases IFNγ, which makes AML cells more vulnerable to NK cell killing via the NKG2C-HLA-E pathway.

This study identifies PKA/CIP4 signaling as a mechanism controlling CIP4 relocalization during NK cell activation, showing phosphorylation at T225 regulates its spatial distribution.

This study evaluates engineered K562 feeder cells for enhancing NK cell expansion and function in ex vivo cultures, showing up to 500-fold higher yields compared to feeder-free systems.

This paper shows CDK4/6 inhibitors make breast cancer cells more susceptible to NK cell therapy by increasing surface proteins that NK cells recognize.

The paper shows JAML expression on NK cells is regulated by tumor microenvironment and MHC class I interaction, with implications for NK cell-mediated tumor killing.

KIR*BLOOM improves KIR genotyping accuracy by modeling copy number and sequencing errors, achieving high precision and recall on whole-genome sequencing data.

The paper shows HIV uses Vpr to increase TRAIL-R2 expression in CD4+ T cells, which enhances NK cell killing through non-canonical TRAIL signaling.

The paper identifies drugs that rewiring the cancer-immune interface by enhancing NK cell function and tumor susceptibility through multimodal screening approaches.

The paper identifies anti-CE1 antibodies that reduce HCC incidence and mortality by mediating NK cell ADCC against ASPH-expressing tumor cells through epitope mimicry.

Intra-tumoral Treg ablation enhances NK cell-mediated tumor control by restoring IL-2 production, effective against both MHC I+ and MHC I- cancers without systemic toxicity.

This study uses dynamic 3D GB spheroids to investigate NK cell-GB crosstalk, identifying cytokine secretion and the CD155 axis as key factors in NK cell cytotoxicity against GB stem-like cells.

This study expands and activates allogeneic canine NK cells ex vivo, demonstrating their safety and in vitro potency for treating metastatic solid tumors.

The paper identifies novel regulators of NK cell development and antiviral function through in vivo screening in mice, with relevance to human health.

The paper shows that NK cell responses to CMV infection differ between infants and adults, influenced by age and T cell immunity, with infant NK cells exhibiting adaptive-like features and tissue seeding.

This study shows that LSD1 ablation in mammary tumor cells reduces NK cell-mediated anti-tumor immunity, leading to increased lung metastasis.

This study shows obesity remodels the lung lipidome, impairing NK cell function and antiviral immunity against influenza, and demonstrates that weight loss can restore these functions.

This study shows that NK cell activation via NKG2D and graft Rae-1e ligand is essential for antibody-mediated kidney allograft rejection, even with high DSA levels.

This study identifies smoking-associated natural killer cell subsets in NSCLC that correlate with survival and response to neoadjuvant chemoimmunotherapy, suggesting their use in therapeutic stratification.

This study compares 6-hour and 18-hour stimulation durations for NK cell degranulation assays and finds the 6-hour protocol is more reliable and efficient.

This paper shows that IL-21-Fc reprograms NK cell metabolism to enhance their function against MHC-I deficient tumors, leading to tumor eradication in preclinical models.

This study develops and tests a dual strategy using NaMiX and TriKE to enhance NK cell cytotoxicity against PDAC, showing improved tumor cell killing in vitro and in humanized mouse models.

This study compares ADCC activity of CD56neg and CD56dim NK cells against EBV-type 1 and 2 Burkitt lymphoma cells, finding EBV-T2 cells are more susceptible to direct cytotoxicity.