TGF-β signaling in diseases

This study shows that 5-Iodotubercidin inhibits EMT by suppressing NFκB-dependent gene expression, and identifies a gene signature predictive of survival in lung and pancreatic cancer.

This study shows that the TGF-β1/mTORC1 signalling axis regulates the transcriptional identity of CTHRC1+ fibroblasts in IPF, supporting mTORC1 as a therapeutic target.

This study identifies SFPQ as a transcriptional repressor of Snail that counteracts TGF-β signaling by inhibiting Snail expression.

The paper solves the crystal structure of the ActB:Fst288 complex and uses computational analysis to explain Fst288's broad antagonistic activity and specificity for activins.

This study identifies KLHL14's role in maintaining thyroid epithelial identity and regulating tissue homeostasis by modulating TGF-β signaling, with implications for thyroid cancer.

This paper identifies co-receptors for a parasite TGFβ antagonist, uses structural data to design cell-type-specific TGFβ modulators, and demonstrates their selective antagonistic effects.

The paper uses local gene editing in mouse tumor models to discover a novel fibroblast state and its impact on the tumor microenvironment.

This study shows Jagged1 promotes ECM remodeling in TNBC by enhancing fibroblast activation and TGFβ signaling, suggesting it as a therapeutic target.

The paper identifies tissue-specific mechanisms of I-Smad function in Drosophila by analyzing the structure and function of Dad in neural and wing tissues.

This study identifies a paracrine-to-autocrine GREM1 signaling shunt in colorectal cancer that promotes metastasis via ACVR1C, highlighting a mechanism of signaling autonomy in advanced stages.

The paper identifies a domain-swapped architecture in latent TGF-β, crucial for its activation through dynamic allostery.

The paper investigates the effect of a PCSK5M452I mutation in MCF10DCIS.com cells, finding it hypomorphic and not responsible for the cell line's characteristics.

The paper identifies a BMP-dependent endocytosis pathway for GREM1 in epithelial cells, showing BMP binding is required for GREM1 uptake and antagonism of BMP signaling.

This study shows that metastatic site influences the function of driver genes like SMAD4 in pancreatic cancer, with organ-specific epigenetic states affecting tumor growth.

This study shows that dynamic regulation of HSF2 drives breast cancer progression by balancing proliferation and invasion through TGF-β signaling.

This paper presents the cryoEM structure of ALK2:BMP6, revealing distinct mechanisms for ALK2's interaction with BMP and activin ligands.

This study shows that TLL1 knockdown reduces prostate cancer progression by enhancing antitumor immunity through increased CD8+ T cell infiltration.

AI-HOPE-TGFbeta is a conversational AI agent that integrates clinical and genomic data to analyze TGF-β pathway alterations in colorectal cancer, revealing population-specific patterns and clinical outcomes.

This paper shows Rudhira regulates TGFβ signaling and microtubule stability during mouse vascular development through both direct and transcriptional mechanisms.

The paper identifies Smad4 and TGF-β1 dependent gene expression biomarkers in intestinal adenomas and colorectal cancer using murine models and RNA sequencing.

The paper develops a high-throughput 3D ECM remodeling assay to identify MEK as a key driver of fibrotic fibroblast activity, showing that MEK-ERK signaling, not TGFβ signaling, drives ECM remodeling.

The paper identifies CTDNEP1-NEP1R1 as the R-SMAD phosphatase and shows how its complex with MAN1 inactivates TGF-β signaling by dephosphorylating R-SMADs in the nucleus.

This study shows that TGFβ1 and RGD peptides work together to drive aggressive behavior in prostate cancer cells using a 3D hydrogel model.

This study investigates how TGF-β affects colorectal cancer tumoroids, finding that aggressive KRAS mutations lead to partial EMT and increased invasiveness.

This study determines the structure of TGF-beta bound to betaglycan and its signaling receptors, revealing mechanisms of ligand selectivity and signal potentiation.

The paper identifies functional binding sites for Smad and Schnurri transcription factors in C. elegans and reveals their roles in collagen secretion and body size regulation.

This study investigates how BMP-9 and BMP-10 form disulfide bonds and dimers, showing that geometric strain, not cysteinylation, reduces dimerization propensity and that residue swaps can reverse this effect.

This study shows that Gα12 and Gα13 proteins are essential for TGF-β-induced myofibroblast differentiation by regulating Smad phosphorylation and receptor expression.