Discover, rate, and discuss biology preprints.

This study identifies tissue-specific metabolic reprogramming in sepsis, showing that mitochondrial adaptations in vital organs, not global dysfunction, underlie sepsis tolerance.

This study investigates sex-specific acute cerebrovascular responses to photothrombotic stroke in mice, revealing that ROCK2 and female sex hormones mediate differences in CBF responses between sexes.

This study identifies a distinct pattern of skeletal muscle dysfunction in a mouse model of long-term post-viral lung disease caused by Sendai virus, showing reduced myofiber size without changes in myofiber type or protein synthesis/degradation markers.

This study shows that reducing dietary isoleucine improves metabolic health, reduces frailty, and extends lifespan in genetically diverse mice.

This study shows neuronal E93 in Drosophila regulates adult metabolism and circadian rhythms by acting in GABA and MIP neurons, linking metamorphosis to metabolic homeostasis.

This study shows that ketone body metabolism declines with age in mice, with sex-dependent differences in metabolic responses to a ketogenic diet.

This study examines motor unit adaptations in human skeletal muscle after 15 days of unilateral limb immobilisation, finding reduced muscle strength relative to mass and changes in motor unit firing and neuromuscular junction transmission.

This study shows SARS-CoV-2 envelope protein alkalinizes ERGIC and lysosomes by acting as a proton channel, affecting viral replication and pathogenicity.

This study examines how elevated temperatures affect Bogong moth activity and mass during aestivation, finding increased activity at higher temperatures and greater wet mass loss.

This study investigates the role of MyBP-C in stabilizing the SRX myosin state in cardiac muscle using transgenic mice and super-resolution microscopy, finding that MyBP-C's N-terminal region is critical for maintaining SRX along the thick filament.

This study uses D2O and MRI to assess how AQP4 loss affects water dynamics in the brain after focal ischemia, finding delayed signal changes in AQP4-knockout mice.

This study shows that amyloid beta 42 from adipose tissue impairs cardiac function in obesity by affecting mitochondrial metabolism, and that neutralizing A{beta} can prevent obesity-induced cardiac dysfunction.

This study shows that nicotinamide riboside improves exercise capacity in ANT1-deficient mice by increasing NAD+ levels and mitochondrial respiration.

This study identifies dynein-mediated trafficking and degradation of nephrin as a key mechanism in diabetic podocytopathy, showing increased dynein expression and its role in nephrin mistrafficking.

This paper identifies IRS4 as a novel regulator of TRPM6 channel activity and Mg2+ homeostasis, showing IRS4 mediates insulin's effect on TRPM6 phosphorylation and Mg2+ absorption.

This study reproduces spatial summation of pain using home-based procedures and finds a link between pain expectations and spatial summation.

This paper shows Varroa destructor steals intact host proteins for rapid development and reproduction, describing this as 'kleptocytosis'.

This study evaluates the accuracy of optical heart rate measurement in three wearable devices under different conditions, finding they meet ANSI/CTA standards for physical activity monitoring.

This study shows that inhibiting MAO-A in cardiomyocytes reduces arrhythmias by improving diastolic calcium control following catecholamine stress.