Discover, rate, and discuss biology preprints.

This study shows that regulating TAK1 activity can improve dystrophic muscle symptoms in a Duchenne muscular dystrophy mouse model.

This pilot study investigates how ovarian hormone levels affect circulating microRNA (cf-miRNA) expression across the menstrual cycle in human plasma, finding associations between cycle phases, hormones, and specific miRNAs.

This study shows that fenretinide reduces obesity and fatty liver but increases ceramides via Smpd3, worsening atherosclerosis in LDLR-/- mice.

This study identifies CD47 as a regulator of insulin secretion and islet transplant outcomes, showing that its inhibition enhances insulin release and transplant efficiency.

This study shows that encoding hunger through neuronal epigenome changes slows aging in Drosophila by altering histone acetylation and BCAA metabolism.

This study examines how low amplitude taVNS affects non-native speech category learning and pupillary responses in adults, finding faster learning with taVNS but no pupillary modulation.

The paper identifies Hippo kinases as inhibitors of PI3K alpha, showing epinephrine activates these kinases to suppress insulin signaling and glucose metabolism.

This study identifies sex-biased proteomic responses to TSWV infection in salivary glands of Frankliniella occidentalis, revealing differential effects on male and female proteomes and saliva composition.

The paper uses machine learning and Drosophila experimental evolution to identify genomic regions causally linked to physiological traits.

This study investigates the role of ATF5 in mitochondrial quality control in skeletal muscle during rest and after acute exercise, finding that ATF5 deficiency leads to impaired mitochondrial function and altered stress responses.

This study examines the relationship between estrogen levels and postural sway in women, finding no significant effect of menstrual cycle phase or estradiol levels on sway.

This study examines how cadence and power affect muscle fascicle shortening velocities, muscle activation, and joint powers during cycling, finding that preferred cadence is not primarily driven by optimizing fascicle velocities.

This paper uses a 3D human atrial myocyte model to study how changes in Ca2+-handling proteins and TATS density affect arrhythmia mechanisms in disease.

This study develops a 3D human atrial myocyte model to investigate how variations in transverse-axial tubule systems (TATS) affect Ca2+ handling and promote arrhythmia through spontaneous Ca2+ release.

This study shows that early life stress increases female mice's susceptibility to metabolic dysfunction and pain when exposed to a high-fat/high-sucrose diet.

This study shows dehydration and infection increase feeding in western flower thrips, likely due to glycogen depletion, affecting their survivorship and disease spread.

The paper examines how fat accumulation in livers with simple steatosis affects liver stiffness, finding that fat softens the liver locally rather than uniformly.

This study shows metformin improves ovarian function and egg production in broiler breeder hens by reducing fat, normalizing follicular hierarchy, and altering hormone levels.

This study shows that low maternal and postnatal protein diets in mice affect skeletal muscle structure and function, while postnatal low protein diet increases bone mass.

This study shows that chronic endurance training in dogs increases arrhythmia susceptibility through electrophysiological and molecular changes.