Discover, rate, and discuss biology preprints.
363,000+ bioRxiv and medRxiv preprints, including those later published in peer-reviewed journals, across 26 biological disciplines.
Recent preprints
- PhysiologybioRxivPreprint
Homeostatic responses to hypoxia by the carotid body and adrenal medulla are based on mutual antagonism between HIF-1α and HIF-2α
G. Yuan, Y.-J. Peng, V. D. Reddy…·N. R. Prabhakar
This study shows that HIF-1α and HIF-2α antagonism in the carotid body and adrenal medulla regulates redox balance and hypoxia responses, maintaining blood pressure and respiration.
DOI 10.1101/2022.07.11.499380 - PhysiologybioRxiv
Wide-pulse electrical stimulation of the quadriceps femoris allows greater maximal evocable torque than conventional stimulation
L. Espeit, T. Lapole, G. Y. Millet…·N. A. Maffiuletti
This study compares maximal evocable torque from conventional and wide-pulse NMES protocols, finding wide-pulse protocols produce greater torque with lower current intensity.
DOI 10.1007/s00421-023-05145-z - PhysiologybioRxivPreprint
Measurement of Cervical Neuronal Activity during Stress Challenge Using Novel Flexible Adhesive Surface Electrodes
Y. Bu, J. F. Kurniawa, J. Prince…·I. Lerman
This paper introduces a novel flexible adhesive electrode array for non-invasive cervical nerve activity monitoring and demonstrates its use in detecting stress-induced neuronal changes.
DOI 10.1101/2022.07.10.499484 - PhysiologybioRxivPreprint
Reliability metrics of outcome measures during the single and double leg drop jump tests
H. Celik, A. Yildirim, E. Unver…·S. A. Cinemre
This study assesses the reliability of outcome measures in single and double leg drop jump tests for collegiate athletes, finding high reliability for key metrics in both tests.
DOI 10.1101/2022.07.10.499453 - PhysiologybioRxiv
High-resolution Spatiotemporal Changes in Dominant Frequency and Structural Organization During Persistent Atrial Fibrillation
T. Pong, J. Aparicio-Valenzuela, T. Obafemi…·A. M. Lee
This study examines changes in dominant frequency and structural organization in persistent atrial fibrillation using a porcine model and high-resolution mapping.
DOI 10.1371/journal.pone.0271846 - PhysiologybioRxiv
Thick Filament Activation Is Different in Fast and Slow-Twitch Skeletal Muscle
H. Gong, W. Ma, M. Regnier, T. Irving
This study uses X-ray diffraction to compare thick filament activation dynamics in fast and slow-twitch rat muscles, finding distinct structural transitions that may explain their differing contraction properties.
DOI 10.1113/jp283574 - PhysiologybioRxivPreprint
Collagen content and cross-links scale with passive stiffness in dystrophic mouse muscles, but are not altered with administration of collagen cross-linking inhibitor beta-aminopropionitrile
S. E. Brashear, R. P. Wohlgemuth, L.-Y. R. Hu…·L. R. Smith
This study investigates the effect of BAPN on collagen cross-linking and passive stiffness in dystrophic mdx mice, finding no reduction in cross-linking but a positive correlation between cross-linking and stiffness.
DOI 10.1101/2022.07.08.499292 - PhysiologyEuropean Respiratory JournalPeer-reviewed
Endothelial PHD2 Deficiency Induces Nitrative Stress via Suppression of Caveolin-1 in Pulmonary Arterial Hypertension
B. Liu, Y. Peng, D. Yi…·Y. Zhao
This study shows that endothelial PHD2 deficiency leads to nitrative stress via suppression of Caveolin-1, contributing to pulmonary arterial hypertension and vascular remodeling.
DOI 10.1183/13993003.02643-2021 - PhysiologybioRxiv
Rescue of alveolar wall liquid secretion blocks fatal lung injury by influenza-staphylococcal coinfection
S. Tang, A. C. De Jesus, D. Chavez…·J. L. Hook
This study shows that influenza virus inhibits alveolar wall liquid secretion, promoting fatal lung injury from staphylococcal infection, and that restoring this secretion protects against lung damage.
DOI 10.1172/jci163402 - PhysiologybioRxiv
Assessment of the Human Placental Microbiome in Early Pregnancy
V. Sharlandjieva, A. Beristain, J. Terry
This study investigates whether bacterial abundance and diversity increase in human placenta with gestational age and if there is an associated shift in decidual immune cell phenotype.
DOI 10.3389/fmed.2023.1096262 - PhysiologybioRxivPreprint
Preparation of large biological samples for high-resolution, hierarchical, multi-modal imaging
J. Brunet, C. L. Walsh, W. L. Wagner…·P. Tafforeau
This paper describes a protocol for preparing large biological samples for high-resolution X-ray microtomography, improving contrast and reducing motion and bubble formation.
- PhysiologyMolecular MetabolismPeer-reviewed
Daily running enhances molecular and physiological circadian rhythms in skeletal muscle
N. Casanova Vallve, D. Duglan, M. E. Vaughan…·K. A. Lamia
This study shows that daily running in mice changes their muscle circadian rhythms and improves exercise performance depending on the time of day.
DOI 10.1016/j.molmet.2022.101504 - PhysiologyScience AdvancesPeer-reviewed
The central clock suffices to drive the majority of circulatory metabolic rhythms
P. Petrus, J. G. Smith, K. B. Koronowski…·S. A. Benitah
The study shows that the central clock, via Syt10-expressing neurons, drives most circulatory metabolic rhythms and rescues glucose intolerance, highlighting its role in circadian communication.
DOI 10.1126/sciadv.abo2896 - PhysiologyComparative Biochemistry and Physiology Part A: Molecular & Integrative PhysiologyPeer-reviewed
Social dominance and reproduction result in increased integration of oxidative state in males of an African cichlid fish
R. J. Fialkowski, S. E. Border, I. Bolitho, P. D. Dijkstra
The paper examines oxidative stress integration in dominant and subordinate male cichlids, finding greater functional integration in dominant males.
DOI 10.1016/j.cbpa.2022.111216 - PhysiologybioRxiv
Responses of the in vitro turtle brain to visual and auditory stimuli during severe hypoxia
M. Ariel, S. Ahuja, D. E. Warren
This study examines how severe hypoxia affects visual and auditory responses in a reduced turtle brain preparation, finding visual responses are reduced while auditory responses remain intact.
DOI 10.1242/jeb.244687 - PhysiologybioRxiv
Endothelial NCK2 Promotes Atherosclerosis Progression in Male but not Female Nck1-null Atheroprone Mice
B. C. Bywaters, G. Pedraza, A. Trache, G. Rivera
This study shows that endothelial NCK2 promotes atherosclerosis in male but not female Nck1-null atheroprone mice, with effects dependent on disease stage and sex.
DOI 10.3389/fcvm.2022.955027 - PhysiologybioRxiv
Sclerostin influences exercise-induced adaptations in body composition and white adipose tissue morphology in male mice
N. Kurgan, J. Stoikos, B. J. Baranowski…·P. Klentrou
This study shows that exercise reduces sclerostin in white adipose tissue, affecting body composition and metabolism in male mice.
DOI 10.1002/jbmr.4768 - PhysiologybioRxiv
Reconstituted depolarization-induced Ca2+ release platform for skeletal muscle disease mutation validation and drug discovery
T. Murayama, N. Kurebayashi, T. Numaga-Tomita…·T. Sakurai
The paper establishes a reconstituted DICR platform in HEK293 cells to validate skeletal muscle disease mutations and test drug candidates.
DOI 10.1085/jgp.202213230