W. Jia

Spatiotemporal transcriptomic profiling reveals the dynamic immunological landscape of alveolar echinococcosis

This study uses spatiotemporal transcriptomics to analyze immune dynamics in E. multilocularis infected mouse liver, identifying key immune cell roles and shifts in immune strategy during infection.

Targeting GFPT2 to reinvigorate immunotherapy in EGFR-mutated NSCLC

This study identifies GFPT2 as a metabolic checkpoint in EGFR-mutated NSCLC that promotes immune evasion, and shows that targeting GFPT2 enhances PD-1 blockade therapy.

MXRA8 promotes adipose tissue whitening to drive obesity

This study identifies MXRA8 as a promoter of adipose tissue whitening that drives obesity, showing its role in reducing UCP1 expression and protecting against obesity in mice.

Selective degradation of multimeric proteins via chemically induced proximity to TRIM21

This study identifies acepromazine as a compound that selectively degrades multimeric proteins via TRIM21 activation, offering a new strategy for targeting disease-related protein assemblies.

Soft and stretchable organic bioelectronics for continuous intra-operative neurophysiological monitoring during microsurgery

This paper introduces a soft, stretchable organic bioelectronic system for continuous intra-operative neurophysiological monitoring during microsurgery, demonstrating improved signal quality and reduced post-operative complications in animal models.

Inhibition of ADORA1 attenuates hepatic steatosis by gut microbiota-derived acetic acid from Astragalus polysaccharides

The paper reports that some data could not be replicated and the manuscript was withdrawn, with parts of the data published elsewhere.

Novel mRNA vaccines encoding Monkeypox virus M1R and A35R protect mice from a lethal virus challenge

This paper develops mRNA vaccines against Monkeypox virus that protect mice from lethal infection, with fusion protein vaccines showing better immune responses than separate protein vaccines.

Single-cell Landscape Analysis Unravels Molecular Programming of the Human B Cell Compartment in Chronic GVHD

This study uses scRNA-Seq to analyze B cells from allo-HCT patients, revealing molecular differences in B cell subsets associated with active versus non-active cGVHD.

FOXP2 confers oncogenic effects in prostate cancer through activating MET signalling

This study identifies FOXP2 as an oncogene in prostate cancer that activates MET signaling, promoting tumorigenicity through both full-length and truncated forms.

Epsin2, a novel target for multiple system atrophy therapy via α-synuclein/FABP7 propagation

This study identifies epsin-2 as a therapeutic target for multiple system atrophy by regulating FABP7/-synuclein hetero-aggregates propagation.

Gut microbiota-derived tryptamine impairs insulin sensitivity

This study identifies tryptamine, a gut microbiota-derived metabolite, as a contributor to insulin resistance in type 2 diabetes through TAAR1-ERK signaling.

Topological supramolecular network enabled highly conductive and stretchable organic bioelectronics

This paper introduces a topological supramolecular network strategy to create highly conductive and stretchable organic bioelectronics with unprecedented performance in physiological environments.

DAB2IP inhibits p53 ubiquitin-mediated degradation by competitively binding to GRP75 and suppresses tumor malignancy in colon cancer

This study identifies DAB2IP as a tumor suppressor in colon cancer that inhibits p53 degradation by competing with GRP75 for binding, thereby enhancing p53 stability and suppressing tumor growth.

YAP1 induces invadopodia formation by transcriptionally activating TIAM1 through its enhancer in breast cancer

This study shows YAP1 promotes breast cancer metastasis by enhancing TIAM1 expression through its enhancer, leading to increased RAC1 activity and invadopodia formation.

Super-dosed butyrate induces a revisable metabolic paralysis through transient mitochondrial reprogramming in the gut-brain axis

This study shows that high-dose sodium butyrate causes reversible metabolic paralysis by inducing transient mitochondrial reprogramming in the brain, specifically through ANT protein activation and proton leak.

Single-cell immune landscape of human recurrent spontaneous abortion

This study uses single-cell RNA-sequencing to analyze decidual and peripheral leukocytes in normal and RSA pregnancies, revealing immune dysregulation in RSA.

Epigenetic feedback and stochastic partitioning during cell division can drive resistance to EMT

This study identifies two mechanisms—epigenetic feedback in the ZEB1/GRHL2 loop and stochastic partitioning during cell division—that can drive resistance to EMT in cancer cells.

Fructose Metabolism Contributes to the Warburg effect

This study shows cancer cells use fructose metabolism to drive the Warburg effect by converting glucose to fructose via polyol pathways and exporting fructose to the tumor microenvironment.

Induction of hyperandrogenism and insulin resistance differentially modulates ferroptosis in uterine and placental tissues of pregnant rats

This study investigates how maternal hyperandrogenism and insulin resistance in pregnant rats affect ferroptosis in uterine and placental tissues, revealing differential molecular and cellular mechanisms.

Variations of gut microbiome profile under different storage conditions and preservation periods: A multi-dimensional evaluation

This study evaluates how different storage conditions, preservation periods, and sequencing platforms affect gut microbiome profiles using 16S rRNA gene sequencing.

A possible role for epigenetic feedback regulation in the dynamics of the Epithelial-Mesenchymal Transition (EMT)

This paper investigates how epigenetic feedback affects EMT dynamics by integrating a feedback term into a computational model and supporting it with experimental data showing prolonged TGFβ exposure impairs reversion to the epithelial state.

A Clostridia-rich microbiota contributes to increased excretion of bile acids in diarrhea-predominant irritable bowel syndrome

This study identifies a Clostridia-rich microbiota as a contributor to excessive bile acid excretion in IBS-D patients through metagenomic and metabolomic analyses.

High-throughput determination of the antigen specificities of T cell receptors in single cells

This paper introduces TetTCR-Seq to link TCR sequences to their antigens in single cells and identifies neo-antigen-specific TCRs with no cross-reactivity.

Flavor compounds in fermented Chinese alcoholic beverage alter gut microbiota and attenuate ethanol-induced liver

This study shows that Chinese Baijiu reduces liver injury in mice by altering gut microbiota and metabolome compared to pure ethanol.