Author

N. Sonenberg

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 2 Cancer Biology· 1 Microbiology· 1 Neuroscience· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Research Focus:host-pathogen & immune response· 4 Organism:human· 4 Research Focus:cell signaling & trafficking· 3 Approach:statistical model· 3 Assay:bulk RNA-seq· 2 Research Focus:gene regulatory network inference· 2 Organism:mouse· 2

Frequent Co-Authors

S. M. Jafarnejad· 3 shared T. Duchaine· 3 shared X. Zhang· 3 shared J. Luo· 2 shared J.-H. Choi· 2 shared P. Naeli· 2 shared R. J. Ladak· 2 shared T. Alain· 2 shared

Activity by Year

2020-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 35 mutual co-author links

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3 shared papersCell Biology

S. M. Jafarnejad

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Repression of mRNA translation initiation by GIGYF1 via blocking the eIF3-eIF4G1 interaction

J.-H. Choi, J. Luo, G. G. Hesketh, S. Guo, A. Pistofidis, R. J. Ladak, Y. An, T. Alain, M. Schmeing, A.-C. Gingras, T. Duchaine, X. Zhang, N. Sonenberg, S. M. Jafarnejad

This study identifies GIGYF1 as a repressor of mRNA translation by disrupting the eIF3-eIF4G1 interaction, enhancing host immune response by derepressing Ifnb1 mRNA.

bioRxiv · Oct 14, 2023Cell Biology

Excitatory neuron-specific suppression of the integrated stress response pathway contributes to autism-related phenotypes in a mouse model of fragile X syndrome

M. Hooshmandi, V. Sharma, C. T. Perez, R. Sood, K. Simbriger, C. Wong, K. C. Lister, A. U. Guzman, T. D. Bartley, C. Rocha, G. Maussion, E. Nadler, P. M. Roque, I. Gantois, J. Popic, , A. Khoutorsky

The paper shows that suppressing the ISR pathway in excitatory neurons of FXS mice leads to autism-like behaviors and that restoring it rescues these phenotypes.

bioRxiv · Apr 24, 2023 · PreprintNeuroscience

SARS-CoV-2 protein NSP2 enhances microRNA-mediated translational repression

P. Naeli, X. Zhang, P. Harris Snell, S. Chatterjee, M. Kamran, R. J. Ladak, N. Orr, T. Duchaine, N. Sonenberg, S. M. Jafarnejad

This study shows that SARS-CoV-2 NSP2 enhances miRNA-mediated translational repression by interacting with Argonaute 2 and the GIGYF2 complex.

bioRxiv · Jan 1, 2023Cell Biology

SARS-CoV-2 impairs interferon production via NSP2-induced repression of mRNA translation

J.-H. Choi, X. Zhang, C. Zhang, D. L. Dai, J. Luo, R. Ladak, Q. Li, S. Wiebe, A. C. H. Liu, X. Ran, J. Yang, P. Naeli, A. Garzia, L. Zhou, N. Mahmood, , N. Sonenberg

This study identifies NSP2-induced repression of Ifnb1 mRNA translation as a mechanism by which SARS-CoV-2 suppresses IFN-β production.

bioRxiv · Jan 19, 2022 · PreprintMicrobiology

The MNK1/2-eIF4E axis contributes to phenotype switching, melanoma progression, and resistance to immunotherapy.

F. Huang, C. Goncalves, M. Bartish, J. Remy-Sarrazin, Q. Guo, A. Emond, W. Yang, D. Plourde, J. Su, M. G. Gimeno, Y. Zhan, M. Attias, A. Galan, T. rzymski, M. Mazan, , S. del Rincon

This study identifies the MNK1/2-eIF4E axis as a driver of melanoma phenotype switching, progression, and immunotherapy resistance, with potential therapeutic targeting.

bioRxiv · May 29, 2020Cancer Biology