X. Hou

SlNAP2 promoted fruit ripening by directly binding the ACS2 promoter and interacting with EIL3

This study identifies SlNAP2 as a NAC transcription factor that promotes tomato fruit ripening by directly binding the ACS2 promoter and interacting with EIL3 to enhance ethylene signaling.

Ventral Morphology and Ecological Implications of Cindarella eucalla (Artiopoda, Xandarellida) from Chengjiang Biota, China

This study reconstructs the morphology of Cindarella eucalla using X-ray computed tomography and fluorescent microscopy, revealing features that suggest it lived in muddy, light-filled environments and had escape capabilities.

Histidine limitation causes alteration in the TOR network and plant development

The paper shows that reduced histidine levels in the sune82 mutant alter the TOR network and affect plant development.

Lestaurtinib's antineoplastic activity converges on JAK/STAT signaling to inhibit advanced forms of therapy resistant ovarian cancer

This study identifies lestaurtinib as a potent inhibitor of ovarian cancer, effective against resistant models, by targeting JAK/STAT signaling and synergizing with standard therapies.

The Interplay Between Nutrition and the Midgut Microbiome of the Mosquito Aedes aegypti Reveals Putative Symbionts.

This study examines how blood and sugar meals affect the midgut microbiome of Aedes aegypti, revealing shifts in microbial diversity and function over time.

Endoplasmic reticulum stress delays choroid development in the HCAR1 knock-out mouse

This study shows that HCAR1 deficiency in RPE cells causes ER stress and impaired choroidal development, which is reversible with ISRIB treatment.

Deep learning-based aberration compensation improves contrast and resolution in fluorescence microscopy

This paper introduces a deep learning method to correct optical aberrations in fluorescence microscopy, improving image quality and enabling better downstream analysis.

Forsythoside A blocks the infection of Avian Infectious Bronchitis Virus through binding S1 subunit

This study shows Forsythoside A inhibits Avian Infectious Bronchitis Virus by binding to its S1 subunit, preventing viral attachment and infection.

Metagenomic analysis of individual mosquitos reveals the ecology of insect viruses

The paper analyzes the virome of 2,438 individual mosquitoes across China to reveal viral diversity, geographic hotspots, and the impact of host phylogeny on viral composition.

Reducing PSY activity fine tunes threshold levels of a cis-carotene-derived signal that regulates the PIF3/HY5 module and plastid biogenesis

The paper identifies PSY genetic variants that fine-tune cis-carotene levels, affecting the PIF3/HY5 module and plastid biogenesis in Arabidopsis.

An Interleukin 9-Zbtb18 axis promotes germinal center development of memory B cells

This study identifies an Il-9-Zbtb18 axis that promotes the development of memory B cells from germinal centers by regulating cell cycle, survival, and GC exit.

Using artificial intelligence to document the hidden RNA virosphere

This study uses a deep learning algorithm to discover highly divergent RNA viruses in metatranscriptomes, identifying 161,979 potential species and 180 supergroups.

Growth-inhibiting effects of the unconventional plant APYRASE 7 of Arabidopsis thaliana influences the LRX1/FER/RALF growth regulatory module

This study identifies APY7 as a negative regulator of cell growth in Arabidopsis, showing it modulates RALF1's growth-inhibiting effect and affects cell wall architecture and extracellular pH.

Kindlin-2 inhibits TNF/NF-kB-caspase 8 pathway in hepatocytes to maintain liver development and function

This study shows Kindlin-2 inhibits the TNF/NF-kB-caspase 8 pathway in hepatocytes, preventing liver fibrosis and dysfunction, and identifies it as a potential therapeutic target for liver diseases.

A simple and efficient in planta transformation method based on the active regeneration capacity of plants

This paper introduces a new plant transformation method called RAPID that achieves high efficiency and speed without tissue culture.

Formation process of the twinning β-form anhydrous guanine platelets in the scallop eyes

This study reports the formation mechanism of twinning β-form anhydrous guanine microplatelets in scallop eyes, revealing an intermediate amorphous phase and a two-step crystallization process.

SARS-CoV-2 spike-induced syncytia are senescent and contribute to exacerbated heart failure

This study links SARS-CoV-2 spike-induced syncytia to cellular senescence and exacerbated heart failure, showing that senolytic drugs and WNK1 inhibitors can mitigate cardiac damage.

Segmented MS/MS acquisition of a1 ion-based strategy for in-depth proteome quantitation

The paper introduces deep-APQ, a proteome quantitation method using segmented MS/MS acquisition of a1 ions, showing improved coverage and accuracy in E. coli proteome analysis.

Inhibitory effects of GT0918 on acute lung injury and the molecular mechanisms of anti-inflammatory response

This study shows GT0918 reduces cytokine release and inflammation in COVID-19 by inhibiting NF-κB and activating NRF2, suggesting its potential for treating both mild and severe cases.

An early Cambrian polyp reveals an anemone-like ancestor for medusozoan cnidarians

The paper redescribes Conicula striata as a stem medusozoan with features of both anthozoans and medusozoans, suggesting an anemone-like ancestor for medusozoan cnidarians.

Total virome characterizations of game animals in China reveals a spectrum of emerging viral pathogens

The paper characterizes the virome of 1725 game animals in China, identifying 71 mammalian viruses, 45 novel, and highlighting potential zoonotic risks.

Before trilobite legs: Pygmaclypeatus daziensis reconsidered and the ancestral appendicular organization of Cambrian artiopods

This paper uses micro-CT to study the appendage structure of Pygmaclypeatus daziensis, revealing its heteronomy and suggesting an ancestral exopodite morphology in Artiopoda.

Ionotropic receptors in the turnip moth Agrotis segetum respond to repellent medium-chain fatty acids

This study identifies and functionally characterizes ionotropic receptors in the turnip moth Agrotis segetum that respond to medium-chain fatty acids, revealing subfunctionalization in ligand specificity evolution.

An exceptionally preserved euarthropod with unique feather-like appendages from the Chengjiang biota

The paper describes a new Cambrian euarthropod with unique feather-like appendages, revealing insights into early limb diversity in stem-group euarthropods.

Characterization of a RAD51C-Silenced High Grade Serous Ovarian Cancer Model During PARP Inhibitor Resistance Development

This study shows that PARPi treatment can reverse RAD51C promoter methylation and restore expression in a high-grade serous ovarian cancer model, while maintaining platinum sensitivity.

Role and Dynamics of Vacuolar pH during Cell-in-Cell mediated Death

This study uses pH-sensitive fluorescent protein to track vacuolar pH changes during cell-in-cell mediated death, revealing distinct pH dynamics in entotic and apoptotic death and their implications for cancer treatment.

A high affinity human monoclonal antibody against Pfs230 binds multiple parasite stages and blocks oocyst formation in mosquitoes

The paper identifies a high-affinity human monoclonal antibody against Pfs230 that blocks oocyst formation in mosquitoes by targeting gamete surfaces.

Direct phosphorylation of HY5 by SPA1 kinase to regulate photomorphogenesis in Arabidopsis

This study shows that SPA1 kinase directly phosphorylates HY5, affecting its stability and activity to regulate photomorphogenesis in Arabidopsis.

Cryo-EM structure of the calcium release-activated calcium channel Orai in an open conformation

The paper presents a cryo-EM structure of the Orai channel in an open conformation, revealing the mechanism of channel opening and its role in Ca2+ entry regulation.

JQ-1 ameliorates schistosomiasis liver fibrosis by suppressing JAK2 and STAT3 activation

This study shows JQ-1 reduces liver fibrosis in Schistosoma-infected mice by inhibiting JAK2/STAT3 signaling in hepatic stellate cells.