Author

A. Ke

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 2 Biochemistry· 1 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 2 Research Focus:protein folding & dynamics· 2 Research Focus:protein structure prediction· 2 Assay:structural biology· 2 Organism:bacteria (other)· 1 Research Focus:differential expression· 1 Assay:DNA methylation· 1

Frequent Co-Authors

A. E. Dolan· 1 shared B. C.-H. Chiu· 1 shared C. He· 1 shared C. Hu· 1 shared C. Sui· 1 shared D. Yang· 1 shared E. Anslyn· 1 shared E. T. Hernandez· 1 shared

Activity by Year

2017-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 18 mutual co-author links

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1 shared paperBiophysics

A. E. Dolan

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Author profile →

4 papers

Recent·Most cited

Exploiting Activation and Inactivation Mechanisms in Type I-C CRISPR-Cas3 for Genome Editing Applications

C. Hu, M. T. Myers, X. Zhou, Z. Hou, M. L. Lozen, Y. Zhang, A. Ke

This study defines the DNA binding and cleavage mechanisms of Type I-C CRISPR-Cas3 using cryo-EM and identifies anti-CRISPR proteins that inhibit its activity in human cells.

bioRxiv · Aug 5, 2023Biochemistry

Local-to-global signal transduction at the core of the Mn2+ sensing riboswitch

K. C. Suddala, I. R. Price, M. Janecek, P. Kührova, S. Dandpat, J. Sponer, P. Banas, A. Ke, N. G. Walter

The paper investigates the Mn2+ sensing yybP-ykoY riboswitch, revealing how local structural changes trigger global signal transduction through RNA dynamics.

bioRxiv · Feb 18, 2019Biophysics

5-Hydroxymethylcytosines from Circulating Cell-free DNA as Diagnostic and Prognostic Markers for Hepatocellular Carcinoma

J. Cai, L. Chen, Z. Zhang, X. Zhang, X. Lu, W. Liu, G. Shi, Y. Ge, P. Gao, Y. Yang, A. Ke, L. Xiao, R. Dong, Y. Zhu, X. Yang, , J. Fan

This study develops a 5-hydroxymethylcytosine (5hmC) diagnostic model from circulating cell-free DNA to detect hepatocellular carcinoma with high accuracy and prognostic value.

bioRxiv · Sep 23, 2018 · PreprintCancer Biology

Assembly and translocation of a CRISPR-Cas primed acquisition complex

M. W. Brown, K. E. Dillard, Y. Xiao, A. E. Dolan, E. T. Hernandez, S. Dahlhauser, Y. Kim, L. R. Myler, E. Anslyn, A. Ke, I. Finkelstein

This study uses single-molecule techniques to characterize the type I-E CRISPR-Cas primed acquisition complex, revealing how Cascade, Cas3, and Cas1-Cas2 coordinate to recognize and acquire foreign DNA.

bioRxiv · Oct 26, 2017Biophysics