Author

A. Manning

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 5 Biophysics· 2 Evolutionary Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Research Focus:cell signaling & trafficking· 4 Research Focus:cell type annotation· 4 Organism:human· 4 Approach:statistical model· 4 Research Focus:development & morphogenesis· 3 Research Focus:chromatin & epigenetic regulation· 2 Approach:deep learning· 2

Frequent Co-Authors

A. S. Zhovmer· 3 shared A. X. Cartagena-Rivera· 3 shared C. Smith· 3 shared E. D. Tabdanov· 3 shared D. Mercadante· 2 shared D. Tsygankov· 2 shared R. K. Singh· 2 shared X. Ma· 2 shared

Activity by Year

2020-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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3 shared papersBiophysics

A. S. Zhovmer

Mutual co-authors in cluster

Author profile →

8 papers

Recent·Most cited

Evolution of a biological thermocouple by adaptation of cytochrome c oxidase in asubterrestrial metazoan

M. N. Guerin, T. S. Ellis, M. J. Ware, A. Manning, A. Coley, A. Amini, G. Chung, K. C. Gunsalus, J. R. Bracht

This study identifies a temperature-sensing adaptation in the cytochrome c oxidase of the Devil Worm, Halicephalobus mephisto, showing how evolutionary changes in mitochondrial function enable temperature-dependent metabolic regulation.

bioRxiv · Dec 5, 2023 · PreprintEvolutionary Biology

Septins Enable T Cell Contact Guidance via Amoeboid-Mesenchymal Switch

A. S. Zhovmer, A. Manning, C. Smith, J. Wang, X. Ma, D. Tsygankov, N. V. Dokholyan, A. X. Cartagena-Rivera, R. Singh, E. D. Tabdanov

This study shows that septins regulate T cell migration modes by switching between amoeboid and mesenchymal movement, with mesenchymal migration relying on microtubules and dynein motors.

bioRxiv · Sep 26, 2023 · PreprintCell Biology

Cortical Dynein Drives Centrosome Clustering in Cells with Centrosome Amplification

D. Mercadante, W. A. Aaron, S. D. Olson, A. Manning

The paper shows cortical dynein relocalization is essential for centrosome clustering and bipolar division in cells with extra centrosomes.

bioRxiv · Aug 4, 2022Cell Biology

Septins Provide Microenvironment Sensing and Cortical Actomyosin Partitioning in Motile Amoeboid T Lymphocytes

A. S. Zhovmer, A. Manning, C. Smith, P. J. Saez, X. Ma, D. Tsygankov, A. X. Cartagena-Rivera, R. K. Singh, E. D. Tabdanov

This paper identifies septins as key regulators of amoeboid motility in T cells by enabling microenvironment sensing and actomyosin partitioning through steric interactions with collagen fibers.

bioRxiv · Jan 18, 2022Biophysics

Distinct stress-dependent signatures of cellular and extracellular tRNA-derived small RNAs (tDRs)

G. Li, A. Manning, A. Bagi, X. Yang, J. Howard, P. P. Chan, T. Sweeney, H. Li, B. D. Laurent, M. I. Kontaridis, L. C. Laurent, K. V. K. Jensen, S. F. Aranki, J. D. Muehlschlegel, R. Kitchen, , S. Das

The paper identifies distinct extracellular tRNA-derived small RNA (tDR) fragmentation signatures associated with different stress responses and shows their potential as biomarkers in human disease.

bioRxiv · Sep 3, 2021Cell Biology

Suv420 enrichment at the centromere limits Aurora B localization and function

C. P. Herlihy, S. Hahn, E. A. Crowley, N. Hermance, A. Manning

This study shows that Suv420 enrichment at centromeres reduces Aurora B localization, leading to mitotic errors and chromosome missegregation, with implications for cancer.

bioRxiv · Jun 14, 2021Cell Biology

Mechanical counterbalance of kinesin and dynein motors in microtubular network regulates cell mechanics, 3D architecture, and mechanosensing

A. S. Zhovmer, A. Manning, C. Smith, J. B. Hayes, D. T. Burnette, A. X. Cartagena-Rivera, R. K. Singh, E. D. Tabdanov

The paper shows dynein and kinesin motors balance microtubule network mechanics, affecting cell shape, adhesion, and mechanosensing through opposing actions on microtubule organization.

bioRxiv · May 25, 2021Biophysics

Modeling Reveals Cortical Dynein-Dependent Fluctuations in Bipolar Spindle Length

D. Mercadante, A. Manning, S. Olson

The paper develops a computational model to study cortical dynein's role in spindle length fluctuations and bipolarity, showing dynein's necessity in counteracting HSET activity.

bioRxiv · Jul 10, 2020Cell Biology