A. Roy

The paper presents two neural network models for predicting and generating stable proteins based on amino acid sequences, showing improved stability in both expert-designed and model-generated proteins.

The paper shows that targeting the AKAP220-PPI-HDAC6 pathway restores renal ciliary homeostasis in ADPKD models by modulating actin dynamics and cilia development.

This study shows that Arabidopsis IPK1 and ITPK1 modulate crosstalk between SA-dependent immunity and phosphate-starvation responses by affecting SA levels and PSI-gene expression.

This paper develops a high-throughput assay to identify inhibitors of HSV-1 ICP0 transactivation, identifying 76 potential inhibitors from 19,000 compounds.

This paper shows that ACIS KEPTIDE prevents SARS-CoV2-induced toxicity and mortality in mice by reducing ACE-2 expression and viral entry.

The paper identifies oncogenic alterations in receptor tyrosine kinases (TKs) and their association with poor survival in bladder cancer patients.

This paper develops new techniques to measure laser pulse fidelity in three-photon microscopy, revealing issues with third-order dispersion and pulse-to-pulse variability that affect imaging quality.

The paper describes a Late Cretaceous fossil down feather that supports the developmental modularity hypothesis in feather evolution by matching a specific developmental stage in the Prum and Brush model.

This paper identifies SARS-CoV-2's Mac1 as a mono-ADP-ribosylhydrolase, showing it binds and hydrolyzes mono-ADP-ribose, with implications for antiviral therapy.

This paper assesses agriculture's impact on planetary boundaries and socio-economic factors, projecting significant declines in safe operating limits by 2050 under inefficient consumption scenarios.

This study identifies heterogeneous leukemia stem cells in JMML using single-cell RNA-sequencing and clonogenic assays, revealing their molecular features and potential therapeutic targets.

This study investigates how pathogenic bacteria use proton-motive force to unfold and secrete virulence effectors efficiently, revealing structural and energetic mechanisms involved.

This paper assesses progress toward SDG 6 in India by analyzing biophysical and social indicators, showing declining water resources and slow social development, and proposes a framework for policy implementation.