Author

A. Singla

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Cell Biology· 2 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Research Focus:cell signaling & trafficking· 3 Research Focus:cell type annotation· 3 Research Focus:cancer & tumor microenvironment· 2 Assay:cryo-EM· 2 Research Focus:protein folding & dynamics· 2 Assay:proteomics· 2 Research Focus:chromatin & epigenetic regulation· 1

Frequent Co-Authors

E. Burstein· 3 shared B. Chen· 2 shared D. A. Kramer· 2 shared D. D. Billadeau· 2 shared D. J. Boesch· 2 shared P. Juneja· 2 shared Y. Han· 2 shared Z. Chen· 2 shared

Activity by Year

2021-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 28 mutual co-author links

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3 shared papersCell Biology

E. Burstein

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Structural basis for Retriever-SNX17 assembly and endosomal sorting

A. Singla, D. J. Boesch, H. Y. J. Fung, C. Ngoka, A. S. Enriquez, R. Song, D. A. Kramer, Y. Han, P. Juneja, D. D. Billadeau, X. Bai, Z. Chen, E. E. Turer, E. Burstein, B. Chen

This study determines the structure of the Retriever-SNX17 complex using cryo-EM, revealing how SNX17 interacts with Retriever to facilitate endosomal sorting of cargo proteins.

bioRxiv · Mar 12, 2024Biochemistry

Structural Organization of the Retriever-CCC Endosomal Recycling Complex

D. J. Boesch, A. Singla, Y. Han, D. A. Kramer, Q. Liu, K. Suzuki, P. Juneja, X. Zhao, X. Long, M. J. Medlyn, D. D. Billadeau, Z. Chen, B. Chen, E. Burstein

This study determines the high-resolution structure of the Retriever-CCC endosomal recycling complex using cryo-EM and reveals how cancer mutations disrupt its function.

bioRxiv · Jun 6, 2023Cell Biology

Targeted inhibition of SCF-SKP2 confers anti-tumor activities resulting in a survival benefit in osteosarcoma

J. Wang, A. Ferrena, S. Singh, V. Viscarret, W. Al-Hardan, O. Aldahamsheh, H. Borjihan, A. Singla, S. Yaguare, J. Tingling, X. Zi, Y. Lo, R. Gorlick, E. L. Schwartz, H. Zhao, , B. H. Hoang

This study shows that inhibiting SKP2 in osteosarcoma reduces tumor growth and improves survival, suggesting it as a potential therapeutic target.

bioRxiv · May 13, 2023 · PreprintCancer Biology

Stimulation of phospholipase Cβ1 by Gαq promotes the assembly of stress granule proteins

A. Qifti, L. Jackson, A. Singla, O. Garwain, S. Scarlata

This study shows that Gαq activation promotes stress granule formation via cytosolic PLCβ1, leading to the assembly of stress granule proteins.

bioRxiv · Sep 26, 2021 · PreprintBiochemistry

Lipid kinases VPS34 and PIKfyve coordinate a phosphoinositide cascade to regulate Retriever-mediated recycling on endosomes

S. S. P. Giridharan, G. S. Luo, P. S. Rivero-Rios, N. S. Steinfeld, H. Tronchere, A. Singla, E. Burstein, D. Billadeau, M. A. Sutton, L. S. Weisman

The paper identifies VPS34 and PIKfyve as regulators of endosomal recycling via a phosphoinositide cascade involving Retriever, SNX17, and CCC complexes.

bioRxiv · May 25, 2021Cell Biology