Author

M. Reth

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 6 Biochemistry· 1 Bioengineering· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 7 Research Focus:cell signaling & trafficking· 6 Organism:human· 6 Assay:proteomics· 6 Research Focus:host-pathogen & immune response· 3 Research Focus:cell type annotation· 2 Assay:cryo-EM· 2 Research Focus:development & morphogenesis· 1

Frequent Co-Authors

D. Saltukoglu· 3 shared K. Anasti· 2 shared K. Cronin· 2 shared S. M. Alam· 2 shared Y. Ortiz· 2 shared A. K. Pane· 1 shared A. P. Kane· 1 shared B. Oezdemir· 1 shared

Activity by Year

2019-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 15 mutual co-author links

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3 shared papersImmunology

D. Saltukoglu

Mutual co-authors in cluster

Author profile →

9 papers

Recent·Most cited

Class-specific sensing of HIV-1 antigens by the B cell antigen receptor depends on the CH1 domain

Y. Ortiz, K. Anasti, A. K. Pane, K. Cronin, S. M. Alam, M. Reth

This study shows that IgM and IgG1 BCRs differ in antigen sensing based on valency, with IgM preferring monovalent and IgG1 preferring polyvalent antigens, and identifies the CH1 domain as responsible for this difference.

bioRxiv · Dec 13, 2023 · PreprintImmunology

Discovering Immunoreceptor Coupling and Organization Motifs (ICOMs)

M. Reth

The paper identifies conserved leucine zipper motifs in transmembrane domains of antigen receptors and coreceptors, suggesting they form an interactome that controls receptor organization and function.

bioRxiv · Jul 21, 2023Immunology

Structural principles of B-cell antigen receptor assembly

Y. Dong, X. Pi, F. Bartels-Burgahn, D. Saltukoglu, Z. Liang, J. Yang, Y. Zheng, F. W. Alt, M. Reth, H. Wu

This paper reports cryo-EM structures of the IgM BCR and its Fab-deleted form, revealing an asymmetric arrangement and novel structural principles of BCR assembly.

bioRxiv · Aug 13, 2022Immunology

Plasma membrane topography governs the three-dimensional dynamic localization of IgM B cell receptor clusters

D. Saltukoglu, B. Oezdemir, M. Holtmannspoetter, R. Reski, J. Piehler, R. Kurre, M. Reth

This study uses lattice light sheet microscopy to show that plasma membrane topography influences the dynamic localization of IgM B cell receptor clusters in Ramos B cells.

bioRxiv · Apr 29, 2022Cell Biology

B cells discriminate HIV-1 Envelope protein affinities by sensing antigen binding association rates

M. A. Hossain, K. Anasti, B. Watts, K. Cronin, A. P. Kane, R. J. Edwards, D. Easterhoff, J. Zhang, W. Rountree, Y. Ortiz, L. Verkoczy, M. Reth, S. M. Alam

This study investigates how B cells distinguish HIV-1 Env proteins based on binding kinetics rather than equilibrium dissociation constants.

bioRxiv · Jan 14, 2022 · PreprintImmunology

Engineered chimeric T cell receptor fusion construct (TRuC)-expressing T cells prevent translational shutdown in SARS-CoV-2-infected cells

I. Godbole, K. Ciminski, O. S. Yousefi, S. Pathan-Chhatbar, D. Saltukoglu, N. Vesper, P. Salavei, J. Strietz, N. Gensch, M. Reth, M. Schwemmle, W. W. Schamel

Engineered TRuC T cells recognize and kill SARS-CoV-2-infected cells without causing cytotoxicity, rescuing translational shutdown.

bioRxiv · Jun 25, 2021 · PreprintBioengineering

Quantitative Proteomics Identifies PTP1B as Modulator of B Cell Antigen Receptor Signaling

J. Schwarz, L. Grundmann, T. Kokot, K. A. Kläsener, S. Fotteler, D. Medgyesi, M. Koehn, M. Reth, B. Warscheid

The paper identifies PTP1B as a negative regulator of B cell antigen receptor signaling by dephosphorylating key receptor and downstream signaling components.

bioRxiv · Mar 30, 2021Biochemistry

CD20 as a gatekeeper of the resting stage of human B cells

K. Klasener, J. Jellusova, G. Andrieux, U. Salzer, C. Boehler, S. N. Steiner, J. B. Albinus, M. F. Cavallari, B. Suess, M. Boerries, R. E. Voll, B. Wollscheid, M. Reth

This study shows CD20 maintains the resting state of human B cells by organizing surface receptors, and its disruption leads to B cell activation and plasma cell differentiation.

bioRxiv · Jul 31, 2020Immunology

TLR-induced reorganization of the IgM-BCR complex regulates B-1 cell responses to infections

H. P. Savage, K. Kläsener, F. L. Smith, M. Reth, N. Baumgarth

This study shows TLR activation in CD5+ B-1 cells reorganizes the IgM-BCR complex, leading to CD5 loss and increased BCR signaling, which is necessary for plasmablast differentiation during infections.

bioRxiv · Apr 2, 2019 · PreprintImmunology